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  • Lectin Array Analysis of Purified Lipooligosaccharide: A Method for the Determination of Molecular Mimicry

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    Author(s)
    Semchenko, Evgeny
    Moutin, Marc
    Korolik, Victoria
    Tiralongo, Joe
    Day, Christopher
    Griffith University Author(s)
    Korolik, Victoria
    Day, Christopher J.
    Tiralongo, Joe
    Semchenko, Evgeny
    Moutin, Marc
    Year published
    2011
    Metadata
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    Abstract
    Surface glycosylation of bacteria is involved in many critical host-microbe interactions. Lectin arrays consisting of diverse carbohydrate binding proteins have proven to be an important tool for evaluating a wide variety of glycosylation, including that present on whole bacteria. However, assessing glycosylation on whole bacteria using lectin arrays may not reflect bacterial glycosylation, but interactions between bacteria and the glycosylation present on lectins. The lipooligosaccharide of Campylobacter jejuni NCTC11168 and 81-176 are known to mimic the human monosialylated gangliosides. This molecular mimicry by C. jejuni ...
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    Surface glycosylation of bacteria is involved in many critical host-microbe interactions. Lectin arrays consisting of diverse carbohydrate binding proteins have proven to be an important tool for evaluating a wide variety of glycosylation, including that present on whole bacteria. However, assessing glycosylation on whole bacteria using lectin arrays may not reflect bacterial glycosylation, but interactions between bacteria and the glycosylation present on lectins. The lipooligosaccharide of Campylobacter jejuni NCTC11168 and 81-176 are known to mimic the human monosialylated gangliosides. This molecular mimicry by C. jejuni can result in the post infection sequelae Guillain-Barr頳yndrome. Using C. jejuni as a model system and a discreet lectin and antibody array, a method, applicable to many organisms has been developed and validated by to screening of the purified lipooligosaccharide of C. jejuni for molecular mimicry to monosialylated gangliodises. In case of C. jejuni, knowing whether clinically important bacterial strains are capable of inducing severe autoimmune responses may aid in prevention and/or early diagnosis of debilitating post infection conditions.
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    Journal Title
    Journal of Glycomics and Lipidomics
    Volume
    1
    Issue
    3
    Publisher URI
    http://www.omicsonline.org/jglhome.php
    Copyright Statement
    © The Author(s) 2011. The attached file is reproduced here in accordance with the copyright policy of the publisher. For information about this journal please refer to the journal’s website or contact the authors.
    Subject
    Microbiology not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/44993
    Collection
    • Journal articles

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