dc.contributor.author | Semchenko, Evgeny | |
dc.contributor.author | Moutin, Marc | |
dc.contributor.author | Korolik, Victoria | |
dc.contributor.author | Tiralongo, Joe | |
dc.contributor.author | Day, Christopher | |
dc.date.accessioned | 2017-05-03T14:16:57Z | |
dc.date.available | 2017-05-03T14:16:57Z | |
dc.date.issued | 2011 | |
dc.date.modified | 2012-05-09T22:52:52Z | |
dc.identifier.issn | 21530637 | |
dc.identifier.uri | http://hdl.handle.net/10072/44993 | |
dc.description.abstract | Surface glycosylation of bacteria is involved in many critical host-microbe interactions. Lectin arrays consisting of diverse carbohydrate binding proteins have proven to be an important tool for evaluating a wide variety of glycosylation, including that present on whole bacteria. However, assessing glycosylation on whole bacteria using lectin arrays may not reflect bacterial glycosylation, but interactions between bacteria and the glycosylation present on lectins. The lipooligosaccharide of Campylobacter jejuni NCTC11168 and 81-176 are known to mimic the human monosialylated gangliosides. This molecular mimicry by C. jejuni can result in the post infection sequelae Guillain-Barr頳yndrome. Using C. jejuni as a model system and a discreet lectin and antibody array, a method, applicable to many organisms has been developed and validated by to screening of the purified lipooligosaccharide of C. jejuni for molecular mimicry to monosialylated gangliodises. In case of C. jejuni, knowing whether clinically important bacterial strains are capable of inducing severe autoimmune responses may aid in prevention and/or early diagnosis of debilitating post infection conditions. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.format.extent | 1305229 bytes | |
dc.format.mimetype | application/pdf | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Omics Publishing Group | |
dc.publisher.place | United States | |
dc.publisher.uri | http://www.omicsonline.org/jglhome.php | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 1000105-1 | |
dc.relation.ispartofpageto | 1000105-5 | |
dc.relation.ispartofissue | 3 | |
dc.relation.ispartofjournal | Journal of Glycomics and Lipidomics | |
dc.relation.ispartofvolume | 1 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Microbiology not elsewhere classified | |
dc.subject.fieldofresearchcode | 060599 | |
dc.title | Lectin Array Analysis of Purified Lipooligosaccharide: A Method for the Determination of Molecular Mimicry | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.faculty | Griffith Sciences, School of Natural Sciences | |
gro.rights.copyright | © The Author(s) 2011. The attached file is reproduced here in accordance with the copyright policy of the publisher. For information about this journal please refer to the journal’s website or contact the authors. | |
gro.date.issued | 2011 | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Korolik, Victoria | |
gro.griffith.author | Day, Christopher J. | |
gro.griffith.author | Tiralongo, Joe | |
gro.griffith.author | Semchenko, Evgeny | |
gro.griffith.author | Moutin, Marc | |