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dc.contributor.authorDay, Christopheren_US
dc.contributor.authorKorolik, Victoriaen_US
dc.contributor.authorMoutin, Marcen_US
dc.contributor.authorSemchenko, Evgenyen_US
dc.contributor.authorTiralongo, Joeen_US
dc.date.accessioned2017-04-04T19:12:18Z
dc.date.available2017-04-04T19:12:18Z
dc.date.issued2011en_US
dc.date.modified2012-05-09T22:52:52Z
dc.identifier.issn21530637en_US
dc.identifier.urihttp://hdl.handle.net/10072/44993
dc.description.abstractSurface glycosylation of bacteria is involved in many critical host-microbe interactions. Lectin arrays consisting of diverse carbohydrate binding proteins have proven to be an important tool for evaluating a wide variety of glycosylation, including that present on whole bacteria. However, assessing glycosylation on whole bacteria using lectin arrays may not reflect bacterial glycosylation, but interactions between bacteria and the glycosylation present on lectins. The lipooligosaccharide of Campylobacter jejuni NCTC11168 and 81-176 are known to mimic the human monosialylated gangliosides. This molecular mimicry by C. jejuni can result in the post infection sequelae Guillain-Barr頳yndrome. Using C. jejuni as a model system and a discreet lectin and antibody array, a method, applicable to many organisms has been developed and validated by to screening of the purified lipooligosaccharide of C. jejuni for molecular mimicry to monosialylated gangliodises. In case of C. jejuni, knowing whether clinically important bacterial strains are capable of inducing severe autoimmune responses may aid in prevention and/or early diagnosis of debilitating post infection conditions.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent1305229 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.publisherOmics Publishing Groupen_US
dc.publisher.placeUnited Statesen_US
dc.publisher.urihttp://www.omicsonline.org/jglhome.phpen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom1000105-1en_US
dc.relation.ispartofpageto1000105-5en_US
dc.relation.ispartofissue3en_US
dc.relation.ispartofjournalJournal of Glycomics and Lipidomicsen_US
dc.relation.ispartofvolume1en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchMicrobiology not elsewhere classifieden_US
dc.subject.fieldofresearchcode060599en_US
dc.titleLectin Array Analysis of Purified Lipooligosaccharide: A Method for the Determination of Molecular Mimicryen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Sciences, School of Natural Sciencesen_US
gro.rights.copyrightCopyright remains with the authors 2011. The attached file is reproduced here in accordance with the copyright policy of the publisher. For information about this journal please refer to the journal’s website or contact the authors.en_US
gro.date.issued2011
gro.hasfulltextFull Text


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