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dc.contributor.authorSemchenko, Evgeny
dc.contributor.authorMoutin, Marc
dc.contributor.authorKorolik, Victoria
dc.contributor.authorTiralongo, Joe
dc.contributor.authorDay, Christopher
dc.date.accessioned2017-05-03T14:16:57Z
dc.date.available2017-05-03T14:16:57Z
dc.date.issued2011
dc.date.modified2012-05-09T22:52:52Z
dc.identifier.issn21530637
dc.identifier.urihttp://hdl.handle.net/10072/44993
dc.description.abstractSurface glycosylation of bacteria is involved in many critical host-microbe interactions. Lectin arrays consisting of diverse carbohydrate binding proteins have proven to be an important tool for evaluating a wide variety of glycosylation, including that present on whole bacteria. However, assessing glycosylation on whole bacteria using lectin arrays may not reflect bacterial glycosylation, but interactions between bacteria and the glycosylation present on lectins. The lipooligosaccharide of Campylobacter jejuni NCTC11168 and 81-176 are known to mimic the human monosialylated gangliosides. This molecular mimicry by C. jejuni can result in the post infection sequelae Guillain-Barr頳yndrome. Using C. jejuni as a model system and a discreet lectin and antibody array, a method, applicable to many organisms has been developed and validated by to screening of the purified lipooligosaccharide of C. jejuni for molecular mimicry to monosialylated gangliodises. In case of C. jejuni, knowing whether clinically important bacterial strains are capable of inducing severe autoimmune responses may aid in prevention and/or early diagnosis of debilitating post infection conditions.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent1305229 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherOmics Publishing Group
dc.publisher.placeUnited States
dc.publisher.urihttp://www.omicsonline.org/jglhome.php
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1000105-1
dc.relation.ispartofpageto1000105-5
dc.relation.ispartofissue3
dc.relation.ispartofjournalJournal of Glycomics and Lipidomics
dc.relation.ispartofvolume1
dc.rights.retentionY
dc.subject.fieldofresearchMicrobiology not elsewhere classified
dc.subject.fieldofresearchcode060599
dc.titleLectin Array Analysis of Purified Lipooligosaccharide: A Method for the Determination of Molecular Mimicry
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, School of Natural Sciences
gro.rights.copyright© The Author(s) 2011. The attached file is reproduced here in accordance with the copyright policy of the publisher. For information about this journal please refer to the journal’s website or contact the authors.
gro.date.issued2011
gro.hasfulltextFull Text
gro.griffith.authorKorolik, Victoria
gro.griffith.authorDay, Christopher J.
gro.griffith.authorTiralongo, Joe
gro.griffith.authorSemchenko, Evgeny
gro.griffith.authorMoutin, Marc


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