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dc.contributor.authorUlett, GC
dc.contributor.authorAdderson, EE
dc.date.accessioned2009-02-20
dc.date.accessioned2012-05-10T22:35:22Z
dc.date.accessioned2017-03-01T23:05:32Z
dc.date.available2017-03-01T23:05:32Z
dc.date.issued2006
dc.date.modified2012-05-10T22:35:22Z
dc.identifier.issn1573-3955
dc.identifier.urihttp://hdl.handle.net/10072/45042
dc.description.abstractApoptosis, or programmed cell death (PCD), is an important physiological mechanism, through which the human immune system regulates homeostasis and responds to diverse forms of cellular damage. PCD may also be involved in immune counteraction to microbial infection. Over the past decade, the amount of research on bacteriainduced PCD has grown tremendously, and the implications of this mechanism on immunity are being elucidated. Some pathogenic bacteria actively trigger the suicide response in critical lineages of leukocytes that orchestrate both the innate and adaptive immune responses; other bacteria proactively prevent PCD to benefit their own survival and persistence. Currently, the microbial virulence factors, which represent the keys to unlocking the suicide response in host cells, are a primary focus of this field. In this review, we discuss these bacterial “apoptosis regulatory molecules” and the apoptotic events they either trigger or prevent, the host target cells of this regulatory activity, and the possible ramifications for immunity to infection. Gram-positive pathogens including Staphylococcus, Streptococcus, Bacillus, Listeria, and Clostridia species are discussed as important agents of human infection that modulate PCD pathways in eukaryotic cells.
dc.description.peerreviewedNo
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBentham Science Publishers Ltd
dc.publisher.placeUSA
dc.publisher.urihttps://benthamscience.com/journals/current-immunology-reviews/service-unavailable/
dc.relation.ispartofbookorjournalCurrent Immunology Reviews
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom119
dc.relation.ispartofpageto141
dc.relation.ispartofissue2
dc.relation.ispartofvolume2
dc.rights.retentionY
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchMedical bacteriology
dc.subject.fieldofresearchcode3204
dc.subject.fieldofresearchcode320701
dc.titleRegulation of Apoptosis by Gram-Positive Bacteria: Mechanistic Diversity and Implications for Immunity
dc.typeReport
dc.type.descriptionU2 - Reviews/Reports
dc.type.codedx
gro.facultyGriffith Health Faculty
gro.date.issued2006
gro.hasfulltextNo Full Text
gro.griffith.authorUlett, Glen C.


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    Contains reports by Griffith authors published for government agencies, industry and other organisations.

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