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dc.contributor.authorWells, Timothy J.en_US
dc.contributor.authorTree, Jai J.en_US
dc.contributor.authorUlett, Glen Charlesen_US
dc.contributor.authorSchembri, Mark A.en_US
dc.date.accessioned2009-02-20en_US
dc.date.accessioned2012-05-10T22:36:12Z
dc.date.accessioned2017-03-01T23:05:32Z
dc.date.available2017-03-01T23:05:32Z
dc.date.issued2007en_US
dc.date.modified2012-05-10T22:36:12Z
dc.identifier.isbnorissn0378-1097en_US
dc.identifier.doi10.1111/j.1574-6968.2007.00833.xen_US
dc.identifier.urihttp://hdl.handle.net/10072/45043
dc.description.abstractAutotransporter proteins constitute a family of outer membrane/secreted proteins that possess unique structural properties that facilitate their independent transport across the bacterial membrane system and final routing to the cell surface. Autotransporter proteins have been identified in a wide range of Gram-negative bacteria and are often associated with virulence functions such as adhesion, aggregation, invasion, biofilm formation and toxicity. The importance of autotransporter proteins is exemplified by the fact that they constitute an essential component of some human vaccines. Autotransporter proteins contain three structural motifs: a signal sequence, a passenger domain and a translocator domain. Here, the structural properties of the passenger and translocator domains of three type Va autotransporter proteins are compared and contrasted, namely pertactin from Bordetella pertussis, the adhesion and penetration protein (Hap) from Haemophilus influenzae and Antigen 43 (Ag43) from Escherichia coli. The Ag43 protein is described in detail to examine how its structure relates to functional properties such as cell adhesion, aggregation and biofilm formation. The widespread occurrence of autotransporter-encoding genes, their apparent uniform role in virulence and their ability to interact with host cells suggest that they may represent rational targets for the design of novel vaccines directed against Gram-negative pathogens.en_US
dc.description.peerreviewedNoen_US
dc.description.publicationstatusYesen_US
dc.publisherElsevier Science B.V. for The Federation of European Microbiological Societiesen_US
dc.publisher.placeThe Netherlandsen_US
dc.relation.ispartofbookorjournalFEMS Microbiology Lettersen_US
dc.relation.ispartofstudentpublicationYen_US
dc.relation.ispartofpagefrom163en_US
dc.relation.ispartofpageto172en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofvolume274en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchMedical Bacteriologyen_US
dc.subject.fieldofresearchcode110801en_US
dc.titleAutotransporter Proteins: Novel Targets at the Bacterial Cell Surfaceen_US
dc.typeReport
dc.type.descriptionMajor Reviews/Reportsen_US
dc.type.codedxen_US
gro.facultyGriffith Health Facultyen_US
gro.date.issued2007
gro.hasfulltextNo Full Text


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