Show simple item record

dc.contributor.authorWells, Timothy J
dc.contributor.authorTree, Jai J
dc.contributor.authorUlett, Glen C
dc.contributor.authorSchembri, Mark A
dc.date.accessioned2009-02-20
dc.date.accessioned2012-05-10T22:36:12Z
dc.date.accessioned2017-03-01T23:05:32Z
dc.date.available2017-03-01T23:05:32Z
dc.date.issued2007
dc.date.modified2012-05-10T22:36:12Z
dc.identifier.issn0378-1097
dc.identifier.doi10.1111/j.1574-6968.2007.00833.x
dc.identifier.urihttp://hdl.handle.net/10072/45043
dc.description.abstractAutotransporter proteins constitute a family of outer membrane/secreted proteins that possess unique structural properties that facilitate their independent transport across the bacterial membrane system and final routing to the cell surface. Autotransporter proteins have been identified in a wide range of Gram-negative bacteria and are often associated with virulence functions such as adhesion, aggregation, invasion, biofilm formation and toxicity. The importance of autotransporter proteins is exemplified by the fact that they constitute an essential component of some human vaccines. Autotransporter proteins contain three structural motifs: a signal sequence, a passenger domain and a translocator domain. Here, the structural properties of the passenger and translocator domains of three type Va autotransporter proteins are compared and contrasted, namely pertactin from Bordetella pertussis, the adhesion and penetration protein (Hap) from Haemophilus influenzae and Antigen 43 (Ag43) from Escherichia coli. The Ag43 protein is described in detail to examine how its structure relates to functional properties such as cell adhesion, aggregation and biofilm formation. The widespread occurrence of autotransporter-encoding genes, their apparent uniform role in virulence and their ability to interact with host cells suggest that they may represent rational targets for the design of novel vaccines directed against Gram-negative pathogens.
dc.description.peerreviewedNo
dc.description.publicationstatusYes
dc.languageEnglish
dc.publisherElsevier Science B.V. for The Federation of European Microbiological Societies
dc.publisher.placeThe Netherlands
dc.relation.ispartofbookorjournalFEMS Microbiology Letters
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrom163
dc.relation.ispartofpageto172
dc.relation.ispartofissue2
dc.relation.ispartofvolume274
dc.rights.retentionY
dc.subject.fieldofresearchMedical Bacteriology
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchAgricultural and Veterinary Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode110801
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode07
dc.subject.fieldofresearchcode11
dc.titleAutotransporter Proteins: Novel Targets at the Bacterial Cell Surface
dc.typeReport
dc.type.descriptionU2 - Reviews/Reports
dc.type.codedx
gro.facultyGriffith Health Faculty
gro.date.issued2007
gro.hasfulltextNo Full Text
gro.griffith.authorUlett, Glen C.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Reports
    Contains reports by Griffith authors published for government agencies, industry and other organisations.

Show simple item record