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dc.contributor.authorM. Zalucki, Yaramahen_US
dc.contributor.authorBeacham, Iforen_US
dc.contributor.authorJennings, Michaelen_US
dc.date.accessioned2017-04-24T08:10:07Z
dc.date.available2017-04-24T08:10:07Z
dc.date.issued2011en_US
dc.date.modified2012-05-31T21:51:08Z
dc.identifier.issn18606768en_US
dc.identifier.doi10.1002/biot.201000334en_US
dc.identifier.urihttp://hdl.handle.net/10072/45323
dc.description.abstractProteins destined for export via the Sec-dependent pathway are synthesized with a short N-terminal signal peptide. A requirement for export is that the proteins are in a translocationally competent state. This is a loosely folded state that allows the protein to pass through the SecYEG apparatus and pass into the periplasm. In order to maintain pre-secretory proteins in an export-competent state, there are many factors that slow the folding of the pre-secretory protein in the cytoplasm. These include cytoplasmic chaperones, such as SecB, and the signal recognition particle, which bind the pre-secretory protein and direct it to the cytoplasmic membrane for export. Recently, evidence has been published that non-optimal codons in the signal sequence are important for a time-critical early event to allow the correct folding of pre-secretory proteins. This review details the recent developments in folding of the signal peptide and the pre-secretory protein.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.publisherWiley - VCH Verlag GmbH & Co. KGaAen_US
dc.publisher.placeGermanyen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom660en_US
dc.relation.ispartofpageto667en_US
dc.relation.ispartofissue6en_US
dc.relation.ispartofjournalBiotechnology Journalen_US
dc.relation.ispartofvolume6en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchMedical Microbiology not elsewhere classifieden_US
dc.subject.fieldofresearchcode110899en_US
dc.titleCoupling between codon usage, translation and protein export in Escherichia colien_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2011
gro.hasfulltextNo Full Text


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