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  • The relevance of non-human primate and rodent malaria models for humans

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    Author(s)
    Langhorne, Jean
    Buffet, Pierre
    Galinski, Mary
    Good, Michael
    Harty, John
    Leroy, Didier
    Mota, Maria
    Pasini, Erica
    Renia, Laurent
    Riley, Eleanor
    Stins, Monique
    Duffy, Patrick
    Griffith University Author(s)
    Good, Michael F.
    Year published
    2011
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    Abstract
    At the 2010 Keystone Symposium on "Malaria: new approaches to understanding Host-Parasite interactions", an extra scientific session to discuss animal models in malaria research was convened at the request of participants. This was prompted by the concern of investigators that skepticism in the malaria community about the use and relevance of animal models, particularly rodent models of severe malaria, has impacted on funding decisions and publication of research using animal models. Several speakers took the opportunity to demonstrate the similarities between findings in rodent models and human severe disease, as well as ...
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    At the 2010 Keystone Symposium on "Malaria: new approaches to understanding Host-Parasite interactions", an extra scientific session to discuss animal models in malaria research was convened at the request of participants. This was prompted by the concern of investigators that skepticism in the malaria community about the use and relevance of animal models, particularly rodent models of severe malaria, has impacted on funding decisions and publication of research using animal models. Several speakers took the opportunity to demonstrate the similarities between findings in rodent models and human severe disease, as well as points of difference. The variety of malaria presentations in the different experimental models parallels the wide diversity of human malaria disease and, therefore, might be viewed as a strength. Many of the key features of human malaria can be replicated in a variety of nonhuman primate models, which are very under-utilized. The importance of animal models in the discovery of new anti-malarial drugs was emphasized. The major conclusions of the session were that experimental and human studies should be more closely linked so that they inform each other, and that there should be wider access to relevant clinical material.
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    Journal Title
    Malaria Journal
    Volume
    10
    DOI
    https://doi.org/10.1186/1475-2875-10-23
    Copyright Statement
    © Langhorne et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Subject
    Microbiology
    Microbiology not elsewhere classified
    Medical microbiology
    Publication URI
    http://hdl.handle.net/10072/45367
    Collection
    • Journal articles

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