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dc.contributor.authorLanghorne, Jean
dc.contributor.authorBuffet, Pierre
dc.contributor.authorGalinski, Mary
dc.contributor.authorGood, Michael
dc.contributor.authorHarty, John
dc.contributor.authorLeroy, Didier
dc.contributor.authorMota, Maria
dc.contributor.authorPasini, Erica
dc.contributor.authorRenia, Laurent
dc.contributor.authorRiley, Eleanor
dc.contributor.authorStins, Monique
dc.contributor.authorDuffy, Patrick
dc.date.accessioned2017-08-10T04:13:57Z
dc.date.available2017-08-10T04:13:57Z
dc.date.issued2011
dc.date.modified2012-05-31T22:27:30Z
dc.identifier.issn14752875
dc.identifier.doi10.1186/1475-2875-10-23
dc.identifier.urihttp://hdl.handle.net/10072/45367
dc.description.abstractAt the 2010 Keystone Symposium on "Malaria: new approaches to understanding Host-Parasite interactions", an extra scientific session to discuss animal models in malaria research was convened at the request of participants. This was prompted by the concern of investigators that skepticism in the malaria community about the use and relevance of animal models, particularly rodent models of severe malaria, has impacted on funding decisions and publication of research using animal models. Several speakers took the opportunity to demonstrate the similarities between findings in rodent models and human severe disease, as well as points of difference. The variety of malaria presentations in the different experimental models parallels the wide diversity of human malaria disease and, therefore, might be viewed as a strength. Many of the key features of human malaria can be replicated in a variety of nonhuman primate models, which are very under-utilized. The importance of animal models in the discovery of new anti-malarial drugs was emphasized. The major conclusions of the session were that experimental and human studies should be more closely linked so that they inform each other, and that there should be wider access to relevant clinical material.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBioMed Central Ltd.
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom23-1
dc.relation.ispartofpageto23-4
dc.relation.ispartofjournalMalaria Journal
dc.relation.ispartofvolume10
dc.rights.retentionY
dc.subject.fieldofresearchMicrobiology not elsewhere classified
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchMedical Microbiology
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode060599
dc.subject.fieldofresearchcode0605
dc.subject.fieldofresearchcode1108
dc.subject.fieldofresearchcode1117
dc.titleThe relevance of non-human primate and rodent malaria models for humans
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/2.0
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© Langhorne et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.date.issued2011
gro.hasfulltextFull Text
gro.griffith.authorGood, Michael F.


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