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  • Identification of molecular genetic factors that influence migraine

    Author(s)
    Maher, Bridget
    Griffiths, Lyn
    Griffith University Author(s)
    Griffiths, Lyn
    Maher, Bridget
    Year published
    2011
    Metadata
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    Abstract
    Abstract Migraine is a common neurological disorder with a strong genetic basis. However, the complex nature of the disorder has meant that few genes or susceptibility loci have been identified and replicated consistently to confirm their involvement in migraine. Approaches to genetic studies of the disorder have included analysis of the rare migraine subtype, familial hemiplegic migraine with several causal genes identified for this severe subtype. However, the exact genetic contributors to the more common migraine subtypes are still to be deciphered. Genomewide studies such as genome-wide association studies and ...
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    Abstract Migraine is a common neurological disorder with a strong genetic basis. However, the complex nature of the disorder has meant that few genes or susceptibility loci have been identified and replicated consistently to confirm their involvement in migraine. Approaches to genetic studies of the disorder have included analysis of the rare migraine subtype, familial hemiplegic migraine with several causal genes identified for this severe subtype. However, the exact genetic contributors to the more common migraine subtypes are still to be deciphered. Genomewide studies such as genome-wide association studies and linkage analysis as well as candidate genes studies have been employed to investigate genes involved in common migraine. Neurological, hormonal and vascular genes are all considered key factors in the pathophysiology of migraine and are a focus of many of these studies. It is clear that the influence of individual genes on the expression of this disorder will vary. Furthermore, the disorder may be dependent on gene-gene and gene-environment interactions that have not yet been considered. In addition, identifying susceptibility genes may require phenotyping methods outside of the International Classification of Headache Disorders II criteria, such as trait component analysis and latent class analysis to better define the ambit of migraine expression.
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    Journal Title
    Molecular Genetics and Genomics: an international journal
    Volume
    285
    Issue
    6
    DOI
    https://doi.org/10.1007/s00438-011-0622-3
    Subject
    Medical and Health Sciences not elsewhere classified
    Genetics
    Plant Biology
    Publication URI
    http://hdl.handle.net/10072/45377
    Collection
    • Journal articles

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