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dc.contributor.authorMaher, Bridget
dc.contributor.authorGriffiths, Lyn
dc.date.accessioned2017-05-03T12:00:19Z
dc.date.available2017-05-03T12:00:19Z
dc.date.issued2011
dc.date.modified2012-05-31T22:41:39Z
dc.identifier.issn16174615
dc.identifier.doi10.1007/s00438-011-0622-3
dc.identifier.urihttp://hdl.handle.net/10072/45377
dc.description.abstractAbstract Migraine is a common neurological disorder with a strong genetic basis. However, the complex nature of the disorder has meant that few genes or susceptibility loci have been identified and replicated consistently to confirm their involvement in migraine. Approaches to genetic studies of the disorder have included analysis of the rare migraine subtype, familial hemiplegic migraine with several causal genes identified for this severe subtype. However, the exact genetic contributors to the more common migraine subtypes are still to be deciphered. Genomewide studies such as genome-wide association studies and linkage analysis as well as candidate genes studies have been employed to investigate genes involved in common migraine. Neurological, hormonal and vascular genes are all considered key factors in the pathophysiology of migraine and are a focus of many of these studies. It is clear that the influence of individual genes on the expression of this disorder will vary. Furthermore, the disorder may be dependent on gene-gene and gene-environment interactions that have not yet been considered. In addition, identifying susceptibility genes may require phenotyping methods outside of the International Classification of Headache Disorders II criteria, such as trait component analysis and latent class analysis to better define the ambit of migraine expression.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.publisher.placeGermany
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom433
dc.relation.ispartofpageto446
dc.relation.ispartofissue6
dc.relation.ispartofjournalMolecular Genetics and Genomics: an international journal
dc.relation.ispartofvolume285
dc.rights.retentionY
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchPlant Biology
dc.subject.fieldofresearchcode119999
dc.subject.fieldofresearchcode0604
dc.subject.fieldofresearchcode0607
dc.titleIdentification of molecular genetic factors that influence migraine
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.date.issued2011
gro.hasfulltextNo Full Text
gro.griffith.authorGriffiths, Lyn
gro.griffith.authorMaher, Bridget


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