dc.contributor.author | C. Sherwin, Justin | |
dc.contributor.author | W. Hewitt, Alex | |
dc.contributor.author | S. Kearns, Lisa | |
dc.contributor.author | Griffiths, Lyn | |
dc.contributor.author | A. Mackey, David | |
dc.contributor.author | T. Coroneo, Minas | |
dc.date.accessioned | 2017-05-03T14:57:20Z | |
dc.date.available | 2017-05-03T14:57:20Z | |
dc.date.issued | 2013 | |
dc.date.modified | 2014-08-28T22:16:11Z | |
dc.identifier.issn | 13953907 | |
dc.identifier.doi | 10.1111/j.1755-3768.2011.02314.x | |
dc.identifier.uri | http://hdl.handle.net/10072/45394 | |
dc.description.abstract | Purpose: To investigate the association between conjunctival ultraviolet autofluorescence (UVAF), a biomarker of ocular ultraviolet radiation (UVR) exposure, and prevalent pterygium. Methods: We conducted a cross-sectional study on Norfolk Island, South Pacific. All permanent residents aged 籵 were invited to participate. Participants completed a sun exposure questionnaire and underwent autorefraction and slit lamp biomicroscope examination. Area of conjunctival UVAF (sum of temporal / nasal area in right and left eyes) was determined using computerized methods. Multivariate logistic and linear regression models were used to estimate the associations with pterygia and UVAF, respectively. Results: Of 641 participants, 70 people (10.9%) had pterygium in one or both eyes, and prevalence was higher in males (15.0% versus 7.7%, p = 0.003). Significant independent associations with pterygium in any eye were UVAF (per 10 mm2) [odds ratio (OR) 1.16, 95% confidence interval (CI) 1.16-1.28, p = 0.002], tanning skin phenotype (OR 2.17, 1.20-3.92, p = 0.010) and spending more than three-quarters of the day outside (OR 2.22, 1.20-4.09, p = 0.011). Increasing quartile of UVAF was associated with increased risk of pterygium following adjustment of age, sex and time outdoors (pTrend = 0.002). Independent associations with increasing UVAF (per 10 mm2) were decreasing age, time outdoors, skin type and male gender (all p < 0.001). UVAF area correlated well with the duration of outdoor activity (pTrend < 0.001). Conclusion: Pterygium occurs in approximately one-tenth of Norfolk Islanders. Increasing conjunctival UVAF is associated with prevalent pterygia, confirming earlier epidemiological, laboratory and ray-tracing studies that pterygia are associated with UVR. Protection from the sun should be encouraged to reduce the prevalence of pterygium in the community. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Wiley-Blackwell Publishing, Inc. | |
dc.publisher.place | United States | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 363 | |
dc.relation.ispartofpageto | 370 | |
dc.relation.ispartofissue | 4 | |
dc.relation.ispartofjournal | Acta Ophthalmologica | |
dc.relation.ispartofvolume | 91 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Ophthalmology and Optometry not elsewhere classified | |
dc.subject.fieldofresearch | Clinical Sciences | |
dc.subject.fieldofresearch | Neurosciences | |
dc.subject.fieldofresearch | Opthalmology and Optometry | |
dc.subject.fieldofresearchcode | 111399 | |
dc.subject.fieldofresearchcode | 1103 | |
dc.subject.fieldofresearchcode | 1109 | |
dc.subject.fieldofresearchcode | 1113 | |
dc.title | The association between pterygium and conjunctival ultraviolet autofluorescence: The Norfolk Island Eye Study | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2013 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Griffiths, Lyn | |