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dc.contributor.authorC. Sherwin, Justin
dc.contributor.authorW. Hewitt, Alex
dc.contributor.authorS. Kearns, Lisa
dc.contributor.authorGriffiths, Lyn
dc.contributor.authorA. Mackey, David
dc.contributor.authorT. Coroneo, Minas
dc.date.accessioned2017-05-03T14:57:20Z
dc.date.available2017-05-03T14:57:20Z
dc.date.issued2013
dc.date.modified2014-08-28T22:16:11Z
dc.identifier.issn13953907
dc.identifier.doi10.1111/j.1755-3768.2011.02314.x
dc.identifier.urihttp://hdl.handle.net/10072/45394
dc.description.abstractPurpose: To investigate the association between conjunctival ultraviolet autofluorescence (UVAF), a biomarker of ocular ultraviolet radiation (UVR) exposure, and prevalent pterygium. Methods: We conducted a cross-sectional study on Norfolk Island, South Pacific. All permanent residents aged 籵 were invited to participate. Participants completed a sun exposure questionnaire and underwent autorefraction and slit lamp biomicroscope examination. Area of conjunctival UVAF (sum of temporal / nasal area in right and left eyes) was determined using computerized methods. Multivariate logistic and linear regression models were used to estimate the associations with pterygia and UVAF, respectively. Results: Of 641 participants, 70 people (10.9%) had pterygium in one or both eyes, and prevalence was higher in males (15.0% versus 7.7%, p = 0.003). Significant independent associations with pterygium in any eye were UVAF (per 10 mm2) [odds ratio (OR) 1.16, 95% confidence interval (CI) 1.16-1.28, p = 0.002], tanning skin phenotype (OR 2.17, 1.20-3.92, p = 0.010) and spending more than three-quarters of the day outside (OR 2.22, 1.20-4.09, p = 0.011). Increasing quartile of UVAF was associated with increased risk of pterygium following adjustment of age, sex and time outdoors (pTrend = 0.002). Independent associations with increasing UVAF (per 10 mm2) were decreasing age, time outdoors, skin type and male gender (all p < 0.001). UVAF area correlated well with the duration of outdoor activity (pTrend < 0.001). Conclusion: Pterygium occurs in approximately one-tenth of Norfolk Islanders. Increasing conjunctival UVAF is associated with prevalent pterygia, confirming earlier epidemiological, laboratory and ray-tracing studies that pterygia are associated with UVR. Protection from the sun should be encouraged to reduce the prevalence of pterygium in the community.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing, Inc.
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom363
dc.relation.ispartofpageto370
dc.relation.ispartofissue4
dc.relation.ispartofjournalActa Ophthalmologica
dc.relation.ispartofvolume91
dc.rights.retentionY
dc.subject.fieldofresearchOphthalmology and Optometry not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchOpthalmology and Optometry
dc.subject.fieldofresearchcode111399
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1109
dc.subject.fieldofresearchcode1113
dc.titleThe association between pterygium and conjunctival ultraviolet autofluorescence: The Norfolk Island Eye Study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2013
gro.hasfulltextNo Full Text
gro.griffith.authorGriffiths, Lyn


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