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  • IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection

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    Author(s)
    B. Ashman, Robert
    Vijayan, Dipti
    Wells, Christine
    Griffith University Author(s)
    Wells, Christine
    Vijayan, Dipti
    Year published
    2011
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    Abstract
    IL-12 is a cytokine with links to both innate and adaptive immunity systems. Inmice, its deletion leads to acute susceptibility to oral infection with the yeast Candida albicans, whereas such mice are resistant to systemic disease.However, it is an essential component of the adaptive response that leads to the generation of Th1-type cytokine responses and protection against disseminated disease. This paper presents an overview of the role of IL-12 in models of systemic and mucosal infection and the possible relationships between them.IL-12 is a cytokine with links to both innate and adaptive immunity systems. Inmice, its deletion leads to acute susceptibility to oral infection with the yeast Candida albicans, whereas such mice are resistant to systemic disease.However, it is an essential component of the adaptive response that leads to the generation of Th1-type cytokine responses and protection against disseminated disease. This paper presents an overview of the role of IL-12 in models of systemic and mucosal infection and the possible relationships between them.
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    Journal Title
    Clinical & Developmental Immunology
    Volume
    686597
    DOI
    https://doi.org/10.1155/2011/686597
    Copyright Statement
    © The Author(s) 2011. The attached file is posted here with permission of the copyright owners for your personal use only. No further distribution permitted.For information about this journal please refer to the journal’s website. The online version of this work is licensed under a Creative Commons License, available at http://creativecommons.org/licenses/by-nc-sa/2.1/au/
    Subject
    Immunology not elsewhere classified
    Immunology
    Publication URI
    http://hdl.handle.net/10072/45399
    Collection
    • Journal articles

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