IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection
MetadataShow full item record
IL-12 is a cytokine with links to both innate and adaptive immunity systems. Inmice, its deletion leads to acute susceptibility to oral infection with the yeast Candida albicans, whereas such mice are resistant to systemic disease.However, it is an essential component of the adaptive response that leads to the generation of Th1-type cytokine responses and protection against disseminated disease. This paper presents an overview of the role of IL-12 in models of systemic and mucosal infection and the possible relationships between them.
Clinical & Developmental Immunology
Copyright remains with the authors 2011. The attached file is posted here with permission of the copyright owners for your personal use only. No further distribution permitted.For information about this journal please refer to the journal’s website. The online version of this work is licensed under a Creative Commons License, available at http://creativecommons.org/licenses/by-nc-sa/2.1/au/
Immunology not elsewhere classified