Show simple item record

dc.contributor.authorIngles, Jodie
dc.contributor.authorYeates, Laura
dc.contributor.authorHunt, Lauren
dc.contributor.authorMcGaughran, Julie
dc.contributor.authorScuffham, Paul A
dc.contributor.authorAtherton, John
dc.contributor.authorSemsarian, Christopher
dc.date.accessioned2017-05-03T11:59:24Z
dc.date.available2017-05-03T11:59:24Z
dc.date.issued2013
dc.date.modified2014-08-28T22:16:32Z
dc.identifier.issn0167-5273
dc.identifier.doi10.1016/j.ijcard.2011.08.083
dc.identifier.urihttp://hdl.handle.net/10072/45407
dc.description.abstractBackground: Health status is an important outcome measure that incorporates multiple dimensions of health, including symptoms, functional status, and psychosocial factors. While health status has been shown to be a predictor for hospital readmission, morbidity and mortality in the heart failure setting, there are limited data in cardiac genetic disease. We examined health status in a number of cardiac genetic disease groups compared to the general Australian population. Methods: A total of 409 individuals were assessed. Individualswith inherited cardiomyopathies [hypertrophic cardiomyopathy (HCM), familial dilated cardiomyopathy (FDC), arrhythmogenic right ventricular cardiomyopathy (ARVC)] and primary arrhythmogenic disorders [long QT syndrome (LQTS), catecholaminergic polymorphic ventricular tachycardia (CPVT)], as well as their first-degree relatives, completed the Medical Outcomes Survey Short Form-36 (SF-36). The physical andmental component scores (PCS andMCS) and SF-6D utility scorewere assessed. Results: Patients with HCM (pb0.001), FDC (pb0.05), and CPVT (pb0.05) were found to have a significantly lower PCS, while patients with LQTS (pb0.01) had a lower MCS. Individuals at risk of HCM (pb0.0001) and genotype positive-phenotype negative HCM patients (pb0.01) both had a higher PCS and utility scores compared to the clinically affected HCMpopulation. Individuals at risk of LQTS had significantly higher PCS than those with a clinical diagnosis of LQTS (pb0.05) and similarly individuals at risk of FDC had significantly higher PCS than FDC patients (pb0.05). In HCM, female gender (p=0.002), presence of co-morbidities (pb0.0001) and higher NYHA functional class (pb0.0001) were predictors of a lower PCS. Conclusions: Patients with a clinical diagnosis of a genetic heart disease have an impaired health status, related to both physical andmental function. Clinical management strategies in such patient groups need to consider health status as an important outcome measure.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeIreland
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom448
dc.relation.ispartofpageto453
dc.relation.ispartofissue3
dc.relation.ispartofjournalInternational Journal of Cardiology
dc.relation.ispartofvolume165
dc.rights.retentionY
dc.subject.fieldofresearchCardiovascular medicine and haematology
dc.subject.fieldofresearchcode3201
dc.titleHealth status of cardiac genetic disease patients and their at-risk relatives
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2013
gro.hasfulltextNo Full Text
gro.griffith.authorScuffham, Paul A.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record