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dc.contributor.authorA. Smart, Neilen_US
dc.contributor.authorKwok, Nigelen_US
dc.contributor.authorJ. Holland, Daviden_US
dc.contributor.authorJayasinghe, Satyajiten_US
dc.contributor.authorGiallauria, Francescoen_US
dc.date.accessioned2017-05-03T13:12:49Z
dc.date.available2017-05-03T13:12:49Z
dc.date.issued2011en_US
dc.date.modified2012-09-14T02:29:30Z
dc.identifier.issn11795549en_US
dc.identifier.doi10.4137/CMC.S4309en_US
dc.identifier.urihttp://hdl.handle.net/10072/45415
dc.description.abstractBucindolol is a non-selective ߭adrenergic receptor blocker with a-1 blocker properties and mild intrinsic sympatholytic activity. The Beta-Blocker Evaluation of Survival Trial (BEST), which is the largest clinical trial of bucindolol in patients with heart failure, was terminated prematurely and failed to show an overall mortality benefit. However, benefits on cardiac mortality and re- hospitalization rates were observed in the BEST trial. Bucindolol has not shown benefits in African Americans, those with significantly low ejection fraction and those in NYHA class IV heart failure. These observations could be due to the exaggerated sympatholytic response to bucindolol in these sub-groups that may be mediated by genetic polymorphisms or changes in gene regulation.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent579971 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherLibertas Academica Ltd.en_US
dc.publisher.placeNew Zealanden_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom55en_US
dc.relation.ispartofpageto66en_US
dc.relation.ispartofjournalClinical Medicine Insights: Oncologyen_US
dc.relation.ispartofvolume5en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchCardiology (incl. Cardiovascular Diseases)en_US
dc.subject.fieldofresearchcode110201en_US
dc.titleBucindolol: A Pharmacogenomic Perspective on Its Use in Chronic Heart Failureen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyright© The Author(s) 2011. The attached file is reproduced here in accordance with the copyright policy of the publisher. For information about this journal please refer to the journal’s website or contact the authors.en_US
gro.date.issued2011
gro.hasfulltextFull Text
gro.griffith.authorJayasinghe, Satyajit R.


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