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  • The migration of olfactory ensheathing cells during development and regeneration

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    Author(s)
    Ekberg, Jenny AK
    Amaya, Daniel
    Mackay-Sim, Alan
    St John, James A
    Griffith University Author(s)
    Mackay-Sim, Alan
    Amaya, Daniel A.
    St John, James A.
    Ekberg, Jenny A.
    Year published
    2012
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    Abstract
    The primary olfactory nervous system is unique in that it continuously renews itself and regenerates after injury. These properties are attributed to the presence of olfactory glia, termed olfactory ensheathing cells (OECs). Evidence is now emerging that individual OEC populations exist with distinct anatomical localisations and physiological properties, but their differential roles have not been determined. Unlike other glia, OECs can migrate from the periphery into the central nervous system, and organised OEC migration can enhance axonal extension after injury. Despite this, the mechanisms regulating OEC migration are ...
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    The primary olfactory nervous system is unique in that it continuously renews itself and regenerates after injury. These properties are attributed to the presence of olfactory glia, termed olfactory ensheathing cells (OECs). Evidence is now emerging that individual OEC populations exist with distinct anatomical localisations and physiological properties, but their differential roles have not been determined. Unlike other glia, OECs can migrate from the periphery into the central nervous system, and organised OEC migration can enhance axonal extension after injury. Despite this, the mechanisms regulating OEC migration are largely unknown. Here, we provide an overview of the roles of OECs in development and adulthood. We review the latest research describing the differences between individual OEC subpopulations and discuss potential regulatory mechanisms for OEC guidance and migration. Using advanced time-lapse techniques, we have obtained novel insights into how OECs behave in a complex multicellular environment which we discuss here with particular focus on cell-cell interactions. Significantly, transplantation of OECs constitutes a promising novel therapy for nerve injuries, but results are highly variable and the method needs improvement. We here review the roles of transplanted OECs in neural repair of damaged neuronal tracts distinct from the primary olfactory nervous system.
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    Journal Title
    NeuroSignals
    Volume
    20
    Issue
    3
    DOI
    https://doi.org/10.1159/000330895
    Copyright Statement
    © 2011 S. Karger AG, Basel. This is the author-manuscript pre-print version of this paper. Reproduced in accordance with the copyright policy of the publisher. This article is copyright protected. Any distribution without written consent from S. Karger AG, Basel is a violation of the copyright.
    Subject
    Central Nervous System
    Peripheral Nervous System
    Biochemistry and Cell Biology
    Neurosciences
    Publication URI
    http://hdl.handle.net/10072/45583
    Collection
    • Journal articles

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