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  • Genetic variation of IL-12B (+1188 region) is associated with its decreased circulating levels and susceptibility to Type 2 diabetes

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    Author(s)
    Yaghini, Narges
    Mahmoodi, Mehdi
    Hassanshahi, Gholamhossein
    Asadikaram, Gholamreza
    Arababadi, Mohammad Kazemi
    Rezaeian, Mohsen
    Sajjadi, Seyed Mohammad Ali
    Kennedy, Derek
    Griffith University Author(s)
    Kennedy, Derek D.
    Year published
    2012
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    Abstract
    Background: Type 2 diabetes mellitus is one of the most common types of endocrine disease and the immune system plays a predominant role in its pathogenesis. Aims: The present study aimed to examine known gene polymorphisms within IL-12B (+1188) region and its circulating serum levels in Type 2 diabetic patients from the southeastern region of Iran and compare them with unrelated controls. Materials & methods: In this clinical study, peripheral blood was collected from 114 Type 2 diabetic patients and 100 healthy controls. Serum levels of IL-12B were measured by ELISA. Genomic DNA was extracted from peripheral blood samples ...
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    Background: Type 2 diabetes mellitus is one of the most common types of endocrine disease and the immune system plays a predominant role in its pathogenesis. Aims: The present study aimed to examine known gene polymorphisms within IL-12B (+1188) region and its circulating serum levels in Type 2 diabetic patients from the southeastern region of Iran and compare them with unrelated controls. Materials & methods: In this clinical study, peripheral blood was collected from 114 Type 2 diabetic patients and 100 healthy controls. Serum levels of IL-12B were measured by ELISA. Genomic DNA was extracted from peripheral blood samples and polymorphisms at the +1188 position of the IL-12B gene were assessed using PCR restriction fragment-length polymorphism. Results: Our findings demonstrated that the AA genotype and the A allele of IL-12B were increased significantly in Type 2 diabetic patients when compared with controls. Our results also showed that the circulating levels of IL-12B were significantly decreased in Type 2 diabetic patients when compared with controls. Conclusion: According to the findings of the current study, we concluded that IL-12B and its +1188 polymorphism may play a prominent role in the pathogenesis of Type 2 diabetes. Further replicative investigations using a larger sample size are essential to identify additional IL-12B genetic variants associated with a risk of Type 2 diabetes.
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    Journal Title
    Biomarkers in Medicine
    Volume
    6
    Issue
    1
    DOI
    https://doi.org/10.2217/BMM.11.84
    Copyright Statement
    © 2012 Future Medicine Ltd. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
    Subject
    Medicinal and biomolecular chemistry
    Medical biochemistry and metabolomics
    Clinical sciences
    Medical genetics (excl. cancer genetics)
    Nephrology and urology
    Publication URI
    http://hdl.handle.net/10072/45633
    Collection
    • Journal articles

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