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dc.contributor.authorYaghini, Nargesen_US
dc.contributor.authorMahmoodi, Mehdien_US
dc.contributor.authorHassanshahi, Gholamhosseinen_US
dc.contributor.authorAsadikaram, Gholamrezaen_US
dc.contributor.authorArababadi, Mohammad Kazemien_US
dc.contributor.authorRezaeian, Mohsenen_US
dc.contributor.authorAli Sajjadi, Seyed Mohammaden_US
dc.contributor.authorKennedy, Dereken_US
dc.date.accessioned2017-05-03T11:12:33Z
dc.date.available2017-05-03T11:12:33Z
dc.date.issued2012en_US
dc.date.modified2013-06-26T03:30:47Z
dc.identifier.issn17520363en_US
dc.identifier.doi10.2217/BMM.11.84en_US
dc.identifier.urihttp://hdl.handle.net/10072/45633
dc.description.abstractBackground: Type 2 diabetes mellitus is one of the most common types of endocrine disease and the immune system plays a predominant role in its pathogenesis. Aims: The present study aimed to examine known gene polymorphisms within IL-12B (+1188) region and its circulating serum levels in Type 2 diabetic patients from the southeastern region of Iran and compare them with unrelated controls. Materials & methods: In this clinical study, peripheral blood was collected from 114 Type 2 diabetic patients and 100 healthy controls. Serum levels of IL-12B were measured by ELISA. Genomic DNA was extracted from peripheral blood samples and polymorphisms at the +1188 position of the IL-12B gene were assessed using PCR restriction fragment-length polymorphism. Results: Our findings demonstrated that the AA genotype and the A allele of IL-12B were increased significantly in Type 2 diabetic patients when compared with controls. Our results also showed that the circulating levels of IL-12B were significantly decreased in Type 2 diabetic patients when compared with controls. Conclusion: According to the findings of the current study, we concluded that IL-12B and its +1188 polymorphism may play a prominent role in the pathogenesis of Type 2 diabetes. Further replicative investigations using a larger sample size are essential to identify additional IL-12B genetic variants associated with a risk of Type 2 diabetes.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent119392 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherFuture Medicine Ltd.en_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom89en_US
dc.relation.ispartofpageto95en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalBiomarkers in Medicineen_US
dc.relation.ispartofvolume6en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchMedical Genetics (excl. Cancer Genetics)en_US
dc.subject.fieldofresearchNephrology and Urologyen_US
dc.subject.fieldofresearchcode110311en_US
dc.subject.fieldofresearchcode110312en_US
dc.titleGenetic variation of IL-12B (+1188 region) is associated with its decreased circulating levels and susceptibility to Type 2 diabetesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2012 Future Medicine Ltd. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.en_US
gro.date.issued2012
gro.hasfulltextFull Text


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