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dc.contributor.authorYaghini, Narges
dc.contributor.authorMahmoodi, Mehdi
dc.contributor.authorHassanshahi, Gholamhossein
dc.contributor.authorAsadikaram, Gholamreza
dc.contributor.authorArababadi, Mohammad Kazemi
dc.contributor.authorRezaeian, Mohsen
dc.contributor.authorSajjadi, Seyed Mohammad Ali
dc.contributor.authorKennedy, Derek
dc.date.accessioned2017-05-03T11:12:33Z
dc.date.available2017-05-03T11:12:33Z
dc.date.issued2012
dc.date.modified2013-06-26T03:30:47Z
dc.identifier.issn1752-0363
dc.identifier.doi10.2217/BMM.11.84
dc.identifier.urihttp://hdl.handle.net/10072/45633
dc.description.abstractBackground: Type 2 diabetes mellitus is one of the most common types of endocrine disease and the immune system plays a predominant role in its pathogenesis. Aims: The present study aimed to examine known gene polymorphisms within IL-12B (+1188) region and its circulating serum levels in Type 2 diabetic patients from the southeastern region of Iran and compare them with unrelated controls. Materials & methods: In this clinical study, peripheral blood was collected from 114 Type 2 diabetic patients and 100 healthy controls. Serum levels of IL-12B were measured by ELISA. Genomic DNA was extracted from peripheral blood samples and polymorphisms at the +1188 position of the IL-12B gene were assessed using PCR restriction fragment-length polymorphism. Results: Our findings demonstrated that the AA genotype and the A allele of IL-12B were increased significantly in Type 2 diabetic patients when compared with controls. Our results also showed that the circulating levels of IL-12B were significantly decreased in Type 2 diabetic patients when compared with controls. Conclusion: According to the findings of the current study, we concluded that IL-12B and its +1188 polymorphism may play a prominent role in the pathogenesis of Type 2 diabetes. Further replicative investigations using a larger sample size are essential to identify additional IL-12B genetic variants associated with a risk of Type 2 diabetes.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent119392 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoen_US
dc.publisherFuture Medicine Ltd.
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom89
dc.relation.ispartofpageto95
dc.relation.ispartofissue1
dc.relation.ispartofjournalBiomarkers in Medicine
dc.relation.ispartofvolume6
dc.rights.retentionY
dc.subject.fieldofresearchMedical Genetics (excl. Cancer Genetics)
dc.subject.fieldofresearchNephrology and Urology
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry
dc.subject.fieldofresearchMedical Biochemistry and Metabolomics
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode110311
dc.subject.fieldofresearchcode110312
dc.subject.fieldofresearchcode0304
dc.subject.fieldofresearchcode1101
dc.subject.fieldofresearchcode1103
dc.titleGenetic variation of IL-12B (+1188 region) is associated with its decreased circulating levels and susceptibility to Type 2 diabetes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2012 Future Medicine Ltd. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
gro.date.issued2012
gro.hasfulltextFull Text
gro.griffith.authorKennedy, Derek D.


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