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dc.contributor.authorVider, J
dc.contributor.authorLehtmaa, J
dc.contributor.authorKullisaar, T
dc.contributor.authorVihalemm, T
dc.contributor.authorZilmer, K
dc.contributor.authorKairane, A
dc.contributor.authorLandõr, A
dc.contributor.authorKaru, T
dc.contributor.authorZilmer, M
dc.date.accessioned2012-04-10
dc.date.accessioned2012-07-12T22:55:06Z
dc.date.accessioned2017-03-01T22:51:43Z
dc.date.available2017-03-01T22:51:43Z
dc.date.issued2001
dc.date.modified2012-07-12T22:55:06Z
dc.identifier.issn0928-4680
dc.identifier.doi10.1016/S0928-4680(00)00057-2
dc.identifier.urihttp://hdl.handle.net/10072/45804
dc.description.abstractThe relationship between exhaustive exercise, oxidative stress, the protective capacity of the antioxidant defense system and cellular immune response has been determined. Exhaustive exercise in well-trained young men (n=19)-induced leukocytosis, decreased proportion of activated-lymphocyte subsets (CD4+ and CD8+) expressing CD69, decreased lymphocyte mitogenic response to concanavalin A (ConA) and phytohemagglutinin (PHA), increased lipid peroxidation, increased total antioxidant status (TAS) and catalase activity, immediately after exercise. Suppressed blood concentration of T-lymphocyte subsets (CD3+, CD4+, CD8+, NK), increased TAS and blood total glutathione (TGSH) in early recovery period (30 min after exercise) were found. Strong positive correlation was observed between TGSH and lymphocyte mitogenic response to ConA and PHA (r=0.85 and 0.85, respectively) immediately after exercise. Moderate positive correlation was observed between TAS and lymphocyte mitogenic response to PHA (r=0.59) immediately after exercise as well as between TAS and lymphocyte mitogenic response to PHA and ConA (r=0.69 and 0.54, respectively). Moderate to weak correlation was observed between TAS and conjugated dienes with exercise (r=0.66) as well as in 30-min recovery (r=0.50). After a short-term bout of exhaustive exercise, immune system was characterized by acute phase response, which was accompanied with oxidative stress. Suppression of the cellular immunity 30 min after exercise shows that this period is not enough for recovery after exhaustive exercise. The results suggest the interactions between exercise-induced oxidative stress and immune response.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.publisherElsevier
dc.publisher.placeIreland
dc.relation.ispartofpagefrom263
dc.relation.ispartofpageto270
dc.relation.ispartofissue4
dc.relation.ispartofjournalPathophysiology
dc.relation.ispartofvolume7
dc.subject.fieldofresearchSports medicine
dc.subject.fieldofresearchMedical physiology
dc.subject.fieldofresearchcode320225
dc.subject.fieldofresearchcode3208
dc.titleAcute immune response in respect to exercise-induced oxidative stress.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codec1x
gro.facultyGriffith Health Faculty
gro.date.issued2001
gro.hasfulltextNo Full Text
gro.griffith.authorVider, Jelena


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