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dc.contributor.convenorNicholas Hoogenraad and Phillip Nagleyen_US
dc.contributor.authorNewman, Judithen_US
dc.contributor.authorCrampton E.M.en_US
dc.contributor.authorKozlov, Sen_US
dc.contributor.authorWatters, Dianne Josephineen_US
dc.date.accessioned2012-07-09en_US
dc.date.accessioned2017-03-01T22:51:46Z
dc.date.available2017-03-01T22:51:46Z
dc.date.issued2010en_US
dc.date.modified2013-09-01T22:57:12Z
dc.identifier.urihttp://hdl.handle.net/10072/45810
dc.description.abstractAtaxia Telangiectasia is a progressive neurodegenerative disorder caused by mutations in the ataxia telangiectasia mutated (atm) gene. Nuclear ATM has a well established role in response to DNA damage, however ATM has also been localized outside the nucleus where it has been demonstrated to participate in the insulin signalling pathway by phosphorylating eIF-4E binding protein(4EBP1). 4EBP1 is a target of Mammalian target of Rapamycin (mTOR) and its phosphorylation releases it from eIF-4E enabling translation of mRNA and protein synthesis. The Tuberous Sclerosis Complex (TSC) proteins, hamartin (TSC1) and tuberin (TSC2) act as a heterodimer to regulate mTOR activity. mTOR exists as two complexes, mTORC1 (rapamycin sensitive) and mTORC2 (insensitive to short term rapamycin). These complexes control many cellular functions including protein synthesis, autophagy, lipid metabolism, mitochondrial biogenesis and cytoskeletal organisation. Mutations in either of the TSC1 or TSC2 genes lead to Tuberous Sclerosis, an autosomal dominant, multisystem disorder of benign tumour growth and neurological abnormalities. Studies in our laboratory have demonstrated for the first time that ATM interacts with both tuberin and hamartin. The effects of ATM deficiency on the mTOR pathway under different growth conditions and stresses will be described.en_US
dc.description.peerreviewedNoen_US
dc.description.publicationstatusYesen_US
dc.format.extent267156 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherhttp://www.asbmb.org.au/ozbio2010/en_US
dc.publisher.placeMelbourneen_US
dc.publisher.urihttp://www.asbmb.org.au/ozbio2010/en_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofconferencenameOzBio 2010 The molecules of life-from discovery to biotechnologyen_US
dc.relation.ispartofconferencetitleProceedings of the Australian Society for Biochemistry and Molecular Biologyen_US
dc.relation.ispartofdatefrom2010-09-26en_US
dc.relation.ispartofdateto2010-10-01en_US
dc.relation.ispartoflocationMelbourneen_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchSignal Transductionen_US
dc.subject.fieldofresearchcode060111en_US
dc.titleInteraction between the Ataxia Telangiectasia Mutated (ATM) and the Tuberous Sclerosis complex (TSC) pathways.en_US
dc.typeConference output
dc.type.descriptionConference Publications (Extract Paper)en_US
dc.type.codee3en_US
gro.facultyFaculty of Science, Environment, Engineering and Technologyen_US
gro.rights.copyrightCopyright remains with the authors 2010. The attached file is reproduced here in accordance with the copyright policy of the publisher. For information about this Conference please refer to the Conference website or contact the authors.en_US
gro.date.issued2010
gro.hasfulltextFull Text


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