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dc.contributor.convenorNicholas Hoogenraad and Phillip Nagley
dc.contributor.authorNewman, Judith
dc.contributor.authorCrampton E.M.
dc.contributor.authorKozlov, S
dc.contributor.authorWatters, Dianne Josephine
dc.date.accessioned2012-07-09
dc.date.accessioned2017-03-01T22:51:46Z
dc.date.available2017-03-01T22:51:46Z
dc.date.issued2010
dc.date.modified2013-09-01T22:57:12Z
dc.identifier.urihttp://hdl.handle.net/10072/45810
dc.description.abstractAtaxia Telangiectasia is a progressive neurodegenerative disorder caused by mutations in the ataxia telangiectasia mutated (atm) gene. Nuclear ATM has a well established role in response to DNA damage, however ATM has also been localized outside the nucleus where it has been demonstrated to participate in the insulin signalling pathway by phosphorylating eIF-4E binding protein(4EBP1). 4EBP1 is a target of Mammalian target of Rapamycin (mTOR) and its phosphorylation releases it from eIF-4E enabling translation of mRNA and protein synthesis. The Tuberous Sclerosis Complex (TSC) proteins, hamartin (TSC1) and tuberin (TSC2) act as a heterodimer to regulate mTOR activity. mTOR exists as two complexes, mTORC1 (rapamycin sensitive) and mTORC2 (insensitive to short term rapamycin). These complexes control many cellular functions including protein synthesis, autophagy, lipid metabolism, mitochondrial biogenesis and cytoskeletal organisation. Mutations in either of the TSC1 or TSC2 genes lead to Tuberous Sclerosis, an autosomal dominant, multisystem disorder of benign tumour growth and neurological abnormalities. Studies in our laboratory have demonstrated for the first time that ATM interacts with both tuberin and hamartin. The effects of ATM deficiency on the mTOR pathway under different growth conditions and stresses will be described.
dc.description.peerreviewedNo
dc.description.publicationstatusYes
dc.format.extent267156 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherhttp://www.asbmb.org.au/ozbio2010/
dc.publisher.placeMelbourne
dc.publisher.urihttp://www.asbmb.org.au/ozbio2010/
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofconferencenameOzBio 2010 The molecules of life-from discovery to biotechnology
dc.relation.ispartofconferencetitleProceedings of the Australian Society for Biochemistry and Molecular Biology
dc.relation.ispartofdatefrom2010-09-26
dc.relation.ispartofdateto2010-10-01
dc.relation.ispartoflocationMelbourne
dc.rights.retentionY
dc.subject.fieldofresearchSignal Transduction
dc.subject.fieldofresearchcode060111
dc.titleInteraction between the Ataxia Telangiectasia Mutated (ATM) and the Tuberous Sclerosis complex (TSC) pathways.
dc.typeConference output
dc.type.descriptionE3 - Conferences (Extract Paper)
dc.type.codee3
gro.facultyFaculty of Science, Environment, Engineering and Technology
gro.rights.copyright© The Author(s) 2010. The attached file is reproduced here in accordance with the copyright policy of the publisher. For information about this Conference please refer to the Conference website or contact the authors.
gro.date.issued2010
gro.hasfulltextFull Text
gro.griffith.authorWatters, Dianne J.
gro.griffith.authorNewman, Judith V.


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