• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Journal articles
    • View Item
    • Home
    • Griffith Research Online
    • Journal articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Whole-genome sequence of Schistosoma haematobium

    Thumbnail
    View/Open
    73894_1.pdf (74.07Kb)
    Author(s)
    Young, Neil D
    Jex, Aaron R
    Li, Bo
    Liu, Shiping
    Yang, Linfeng
    Xiong, Zijun
    Li, Yingrui
    Cantacessi, Cinzia
    Hall, Ross S
    Xu, Xun
    Chen, Fangyuan
    Wu, Xuan
    Zerlotini, Adhemar
    Oliveira, Guilherme
    Hofmann, Andreas
    Zhang, Guojie
    Fang, Xiaodong
    Kang, Yi
    Campbell, Bronwyn E
    Loukas, Alex
    Ranganathan, Shoba
    Rollinson, David
    Rinaldi, Gabriel
    Brindley, Paul J
    Yang, Huanming
    Wang, Jun
    Wang, Jian
    Gasser, Robin B
    Griffith University Author(s)
    Hofmann, Andreas
    Year published
    2012
    Metadata
    Show full item record
    Abstract
    Schistosomiasis is a neglected tropical disease caused by blood flukes (genus Schistosoma; schistosomes) and affecting 200 million people worldwide1. No vaccines are available, and treatment relies on one drug, praziquantel2. Schistosoma haematobium has come into the spotlight as a major cause of urogenital disease, as an agent linked to bladder cancer1,3 and as a predisposing factor for HIV/AIDS4,5. The parasite is transmitted to humans from freshwater snails1. Worms dwell in blood vessels and release eggs that become embedded in the bladder wall to elicit chronic immune-mediated disease6 and induce squamous cell carcinoma7. ...
    View more >
    Schistosomiasis is a neglected tropical disease caused by blood flukes (genus Schistosoma; schistosomes) and affecting 200 million people worldwide1. No vaccines are available, and treatment relies on one drug, praziquantel2. Schistosoma haematobium has come into the spotlight as a major cause of urogenital disease, as an agent linked to bladder cancer1,3 and as a predisposing factor for HIV/AIDS4,5. The parasite is transmitted to humans from freshwater snails1. Worms dwell in blood vessels and release eggs that become embedded in the bladder wall to elicit chronic immune-mediated disease6 and induce squamous cell carcinoma7. Here we sequenced the 385-Mb genome of S. haematobium using Illumina-based technology at 74-fold coverage and compared it to sequences from related parasites8,9. We included genome annotation based on function, gene ontology, networking and pathway mapping. This genome now provides an unprecedented resource for many fundamental research areas and shows great promise for the design of new disease interventions.
    View less >
    Journal Title
    Nature Genetics
    Volume
    44
    Issue
    2
    DOI
    https://doi.org/10.1038/ng.1065
    Copyright Statement
    © 2012 Nature Publishing Group. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
    Subject
    Biological sciences
    Structural biology (incl. macromolecular modelling)
    Biomedical and clinical sciences
    Publication URI
    http://hdl.handle.net/10072/45821
    Collection
    • Journal articles

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander