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dc.contributor.authorVider, Jelenaen_US
dc.date.accessioned2012-04-10en_US
dc.date.accessioned2012-07-12T23:33:15Z
dc.date.accessioned2017-03-01T22:51:56Z
dc.date.available2017-03-01T22:51:56Z
dc.date.issued2002en_US
dc.date.modified2012-07-12T23:33:15Z
dc.identifier.issn0905-7188en_US
dc.identifier.doi10.1034/j.1600-0838.2002.120307.xen_US
dc.identifier.urihttp://hdl.handle.net/10072/45840
dc.description.abstractThe aims of our study were to assess whether endurance training strengthens glutathione-dependent antioxidant defenses and decreases oxidative stress in experimental diabetes. Streptozotocin-induced diabetic rats were divided into trained and untrained groups, which were further divided into resting and acute exercise groups. Endurance training consisted of treadmill running for 8 weeks. For acute exhaustive exercise, graded treadmill running was conducted until exhaustion. Eight weeks' treadmill training increased the endurance, favorably decreased lipid peroxidation as measured by thiobarbituric acid reactive substances but not conjugated dienes levels in kidney and vastus lateralis muscle and upregulated glutathione peroxidase in red gastrocnemius muscle. However, it adversely decreased total glutathione level and glutathione peroxidase activity in kidney. Acute exhaustive exercise up-regulated glutathione peroxidase activity in liver. Endurance training did not prevent the increase in thiobarbituric acid reactive substances level in liver due to acute exhaustive exercise. Activities of glutathione disulfide reductase and glutathione S-transferase were not affected. Even though endurance training appeared to upregulate glutathione dependent antioxidant defense in skeletal muscle and to decrease lipid peroxidation in kidney and vastus lateralis muscle as measured by TBARS, our results suggests that beneficial effects of 8 weeks of endurance training are limited in this rat model of uncontrolled diabetes mellitus.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.publisherBlackwell Munksgaarden_US
dc.publisher.placeCopenhagen, Denmarken_US
dc.relation.ispartofpagefrom163en_US
dc.relation.ispartofpageto170en_US
dc.relation.ispartofissue3en_US
dc.relation.ispartofjournalScandinavian Journal of Medicine & Science in Sportsen_US
dc.relation.ispartofvolume12en_US
dc.subject.fieldofresearchSports Medicineen_US
dc.subject.fieldofresearchcode110604en_US
dc.titleEffects of endurance training on tissue glutathione homeostasis and lipid peroxidation in streptozotocin-induced diabetic rats.en_US
dc.typeJournal article
dc.type.descriptionJournal Articles (Refereed Article)en_US
dc.type.codec1xen_US
gro.facultyGriffith Health Facultyen_US
gro.date.issued2002
gro.hasfulltextNo Full Text


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