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  • Protein crystal structures with ferrocene and ruthenocene-based enzyme inhibitors

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    Author(s)
    Salmon, Adam J
    Williams, Michael L
    Hofmann, Andreas
    Poulsen, Sally-Ann
    Griffith University Author(s)
    Poulsen, Sally-Ann
    Year published
    2012
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    Abstract
    We have determined the protein X-ray crystal structures of four organometallic inhibitors in complex with their target enzyme carbonic anhydrase II. The barrel-shaped hydrophobic ferrocene and ruthenocene moieties have provided a structure-based avenue to better occupy the hydrophobic binding patch within the enzyme active site.We have determined the protein X-ray crystal structures of four organometallic inhibitors in complex with their target enzyme carbonic anhydrase II. The barrel-shaped hydrophobic ferrocene and ruthenocene moieties have provided a structure-based avenue to better occupy the hydrophobic binding patch within the enzyme active site.
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    Journal Title
    Chemical Communications
    Volume
    48
    Issue
    17
    DOI
    https://doi.org/10.1039/c2cc15625c
    Copyright Statement
    © 2012 Royal Society of Chemistry. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
    Subject
    Chemical sciences
    Biologically active molecules
    Publication URI
    http://hdl.handle.net/10072/45849
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    • Journal articles

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