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  • Physical exercise induces activation of NF-kappaB in human peripheral blood lymphocytes

    Author(s)
    Vider, J
    Laaksonen, DE
    Kilk, A
    Atalay, M
    Lehtmaa, J
    Zilmer, M
    Sen, CK
    Griffith University Author(s)
    Vider, Jelena
    Year published
    2001
    Metadata
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    Abstract
    Current understanding of nuclear factor-kappaB (NF-kappaB) activation is derived mostly from in vitro studies, and in vivo human data are limited. This study provides first evidence showing that physical exercise (80% maximal O2 consumption, 1 h) may trigger NF-kappaB activation, as determined by electrophoretic mobility shift assay, in peripheral blood lymphocytes of physically fit young men. Supershift assay showed that the NF-kappaB protein complex contained the transcriptionally active p65 protein. Plasma levels of NF-kappaB-directed gene products such as tumor necrosis factor-alpha and interleukin-2 receptor confirmed ...
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    Current understanding of nuclear factor-kappaB (NF-kappaB) activation is derived mostly from in vitro studies, and in vivo human data are limited. This study provides first evidence showing that physical exercise (80% maximal O2 consumption, 1 h) may trigger NF-kappaB activation, as determined by electrophoretic mobility shift assay, in peripheral blood lymphocytes of physically fit young men. Supershift assay showed that the NF-kappaB protein complex contained the transcriptionally active p65 protein. Plasma levels of NF-kappaB-directed gene products such as tumor necrosis factor-alpha and interleukin-2 receptor confirmed that physical exercise caused NF-kappaB transactivation. Exercise-induced NF-kappaB activation in lymphocytes was associated with elevated levels of lipid peroxidation by-products in the plasma.
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    Journal Title
    Antioxidents & Redox Signalling
    Volume
    3
    Issue
    6
    DOI
    https://doi.org/10.1089/152308601317203639
    Subject
    Biochemistry and cell biology
    Medical biochemistry and metabolomics
    Sports medicine
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/45850
    Collection
    • Journal articles

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