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dc.contributor.authorVider, J
dc.contributor.authorLaaksonen, DE
dc.contributor.authorKilk, A
dc.contributor.authorAtalay, M
dc.contributor.authorLehtmaa, J
dc.contributor.authorZilmer, M
dc.contributor.authorSen, CK
dc.date.accessioned2012-04-10
dc.date.accessioned2012-07-12T23:43:56Z
dc.date.accessioned2017-03-01T22:52:02Z
dc.date.available2017-03-01T22:52:02Z
dc.date.issued2001
dc.date.modified2012-07-12T23:43:56Z
dc.identifier.issn1523-0864
dc.identifier.doi10.1089/152308601317203639
dc.identifier.urihttp://hdl.handle.net/10072/45850
dc.description.abstractCurrent understanding of nuclear factor-kappaB (NF-kappaB) activation is derived mostly from in vitro studies, and in vivo human data are limited. This study provides first evidence showing that physical exercise (80% maximal O2 consumption, 1 h) may trigger NF-kappaB activation, as determined by electrophoretic mobility shift assay, in peripheral blood lymphocytes of physically fit young men. Supershift assay showed that the NF-kappaB protein complex contained the transcriptionally active p65 protein. Plasma levels of NF-kappaB-directed gene products such as tumor necrosis factor-alpha and interleukin-2 receptor confirmed that physical exercise caused NF-kappaB transactivation. Exercise-induced NF-kappaB activation in lymphocytes was associated with elevated levels of lipid peroxidation by-products in the plasma.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.publisherMary Ann Liebert, Inc. Publishers
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom1131
dc.relation.ispartofpageto1137
dc.relation.ispartofissue6
dc.relation.ispartofjournalAntioxidents & Redox Signalling
dc.relation.ispartofvolume3
dc.subject.fieldofresearchSports Medicine
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchMedical Biochemistry and Metabolomics
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode110604
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode1101
dc.subject.fieldofresearchcode1115
dc.titlePhysical exercise induces activation of NF-kappaB in human peripheral blood lymphocytes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codec1x
gro.facultyGriffith Health Faculty
gro.date.issued2001
gro.hasfulltextNo Full Text
gro.griffith.authorVider, Jelena


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