Tomentosones A and B, hexacyclic phloroglucinol derivatives from the Thai shrub Rhodomyrtus tomentosa
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Two phloroglucinols named tomentosones A and B (1 and 2) that each possess a novel hexacyclic ring system were isolated from the CH2Cl2 extract of Rhodomyrtus tomentosa leaves. Their structures were elucidated from analyses of 2D NMR spectroscopic data. Tomentosone A inhibited the growth of chloroquine-resistant and -sensitive strains of the malaria parasite Plasmodium falciparum, with IC50 values of 1.49 占and 1.0 卬 respectively, while tomentosone B was significantly less active.
Journal of Organic Chemistry
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Natural Products Chemistry