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  • Drugs that Kill Cancer Stem-like Cells

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    ZobalovaPUB921.pdf (974.3Kb)
    Author(s)
    Zobalova, Renata
    Stantic, Marina
    Stapelberg, Michael
    Prokopova, Katerina
    Dong, Lan-feng
    Truksa, Jaroslav
    Neuzil, Jiri
    Griffith University Author(s)
    Neuzil, Jiri
    Stapelberg, Michael
    Zobalova, Renata
    Stantic, Marina
    Dong, Lan-feng
    Year published
    2011
    Metadata
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    Abstract
    The hallmarks of cancer include processes like self-sufficiency for growth signals, insensitivity to growth-inhibitory (anti-growth) signals, evasion of programmed cell death (apoptosis), unlimited replicative potential, sustained angiogenesis, and tissue invasion and metastasis (Hanahan & Weinberg, 2000). Recent research dictates that these definitions, while valid, ought to be enriched. That is, we should also consider tumours as a heterogeneous ‘collection of cancer cells’ with a hierarchy. This ‘hierarchical hypothesis’ tells us that tumours contain a minute (sometimes very small) sub-set of cells with distinct properties ...
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    The hallmarks of cancer include processes like self-sufficiency for growth signals, insensitivity to growth-inhibitory (anti-growth) signals, evasion of programmed cell death (apoptosis), unlimited replicative potential, sustained angiogenesis, and tissue invasion and metastasis (Hanahan & Weinberg, 2000). Recent research dictates that these definitions, while valid, ought to be enriched. That is, we should also consider tumours as a heterogeneous ‘collection of cancer cells’ with a hierarchy. This ‘hierarchical hypothesis’ tells us that tumours contain a minute (sometimes very small) sub-set of cells with distinct properties from the bulk of the tumour mass (D’Amour & Gage, 2002; Visvader & Lindeman, 2008; Visvader, 2009). These cells feature certain characteristics inherent to stem cells, including the capacity of self-renewal, asymmetric division and differentiation. They have also a very high propensity to form tumours. Therefore these cells are referred to as cancer stem cells (CSC) or cancer stem-like cells or, better, tumour-initiating cells (TICs). The terminology, while not too important, may be misleading though, since the term ‘cancer stem cells’ implies that we are dealing with true stem cells, which is not possible to reconcile with at this stage, perhaps even more so, since the origin of CSCs is not exactly known.
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    Book Title
    Cancer Stem Cells Theories and Practice
    Publisher URI
    http://www.intechweb.org/
    DOI
    https://doi.org/10.5772/13588
    Copyright Statement
    Copyright 2011 Zobalova et al.; licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Subject
    Cancer Cell Biology
    Publication URI
    http://hdl.handle.net/10072/45966
    Collection
    • Book chapters

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