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dc.contributor.authorZobalova, Renata
dc.contributor.authorStantic, Marina
dc.contributor.authorStapelberg, Michael
dc.contributor.authorProkopova, Katerina
dc.contributor.authorDong, Lan-feng
dc.contributor.authorTruksa, Jaroslav
dc.contributor.authorNeuzil, Jiri
dc.contributor.editorStanley Shostak
dc.date.accessioned2018-01-10T23:33:04Z
dc.date.available2018-01-10T23:33:04Z
dc.date.issued2011
dc.date.modified2012-07-16T23:15:49Z
dc.identifier.isbn9789533072258
dc.identifier.doi10.5772/13588
dc.identifier.urihttp://hdl.handle.net/10072/45966
dc.description.abstractThe hallmarks of cancer include processes like self-sufficiency for growth signals, insensitivity to growth-inhibitory (anti-growth) signals, evasion of programmed cell death (apoptosis), unlimited replicative potential, sustained angiogenesis, and tissue invasion and metastasis (Hanahan & Weinberg, 2000). Recent research dictates that these definitions, while valid, ought to be enriched. That is, we should also consider tumours as a heterogeneous ‘collection of cancer cells’ with a hierarchy. This ‘hierarchical hypothesis’ tells us that tumours contain a minute (sometimes very small) sub-set of cells with distinct properties from the bulk of the tumour mass (D’Amour & Gage, 2002; Visvader & Lindeman, 2008; Visvader, 2009). These cells feature certain characteristics inherent to stem cells, including the capacity of self-renewal, asymmetric division and differentiation. They have also a very high propensity to form tumours. Therefore these cells are referred to as cancer stem cells (CSC) or cancer stem-like cells or, better, tumour-initiating cells (TICs). The terminology, while not too important, may be misleading though, since the term ‘cancer stem cells’ implies that we are dealing with true stem cells, which is not possible to reconcile with at this stage, perhaps even more so, since the origin of CSCs is not exactly known.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherInTech
dc.publisher.placeCroatia
dc.publisher.urihttp://www.intechweb.org/
dc.relation.ispartofbooktitleCancer Stem Cells Theories and Practice
dc.relation.ispartofchapter18
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom361
dc.relation.ispartofpageto378
dc.rights.retentionY
dc.subject.fieldofresearchCancer Cell Biology
dc.subject.fieldofresearchcode111201
dc.titleDrugs that Kill Cancer Stem-like Cells
dc.typeBook chapter
dc.type.descriptionB1 - Chapters
dc.type.codeB - Book Chapters
dcterms.licensehttp://creativecommons.org/licenses/by/3.0
gro.facultyGriffith Health, School of Medical Science
gro.rights.copyrightCopyright 2011 Zobalova et al.; licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.date.issued2011
gro.hasfulltextFull Text
gro.griffith.authorNeuzil, Jiri
gro.griffith.authorStapelberg, Michael
gro.griffith.authorZobalova, Renata
gro.griffith.authorStantic, Marina
gro.griffith.authorDong, Lan-feng


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