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dc.contributor.authorOwen, Suzzanneen_US
dc.contributor.authorMassa, Helenen_US
dc.contributor.authorRose'Meyer, Roselynen_US
dc.contributor.editorM.C. Michaelen_US
dc.date.accessioned2017-05-03T13:17:32Z
dc.date.available2017-05-03T13:17:32Z
dc.date.issued2012en_US
dc.date.modified2013-06-27T00:09:11Z
dc.identifier.issn00281298en_US
dc.identifier.doi10.1007/s00210-011-0722-yen_US
dc.identifier.urihttp://hdl.handle.net/10072/46078
dc.description.abstractThis study examined the effect of age, ovariectomy and dietary phytoestrogen ingestion on adenosine A2B receptor mediated relaxant responses and mRNA expression of adenosine receptor subtypes in the rat isolated bladder. Female Wistar rats (8 weeks) were anaesthetised and the ovaries were removed (ovx) or left intact (sham). Rats were fed either normal rat chow (soy, phytoestrogens) or a non-soy (phytoestrogen free) diet. Isolated bladder from rats aged 12, 24 or 52 weeks were pre-contracted with 3 占carbachol prior to a concentration response curve to 5'-(N-ethylcarboxamido) adenosine (NECA) being obtained. In 12-week-old rats, the bladder exhibited enhanced relaxant responses to NECA in soy-fed rats (P<0.05), whilst at 24 weeks of age, the relaxant responses to NECA were attenuated in all the groups studied except soy-treated sham rat bladders in which the relaxant responses were enhanced. At 52 weeks of age, no relaxant effects were observed in any of the treatment groups and NECA-induced contractile responses occurred. In all bladders, the adenosine A2B receptor was the most abundantly expressed. In bladders from young and mature female rats, the mRNA expression of adenosine receptors (A1, A2A and A2B) was lowest in the bladder from non-soy-fed ovariectomised animals and the use of phytoestrogens in the diet increased the mRNA expression of these receptors (P<0.05).While a soy diet improves the relaxant effects to the adenosine analogue via adenosine A2B receptors in bladders from younger rats, the benefits are lost with advancing age.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent202117 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherSpringeren_US
dc.publisher.placeGermanyen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom539en_US
dc.relation.ispartofpageto549en_US
dc.relation.ispartofissue5en_US
dc.relation.ispartofjournalNaunyn-Schmiedeberg Archives of Pharmacologyen_US
dc.relation.ispartofvolume385en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchBasic Pharmacologyen_US
dc.subject.fieldofresearchcode111501en_US
dc.titleLoss of adenosine A2B receptor mediated relaxant responses in the aged female rat bladder; effects of dietary phytoestrogensen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Nursing and Midwiferyen_US
gro.rights.copyrightCopyright 2012 Springer-Verlag. This is an electronic version of an article published in Naunyn-Schmiedeberg's Archives of Pharmacology, May 2012, Volume 385, Issue 5, pp 539-549. Naunyn-Schmiedeberg's Archives of Pharmacology is available online at: http://link.springer.com// with the open URL of your article.en_US
gro.date.issued2012
gro.hasfulltextFull Text


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