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  • DMAN: a Java tool for analysis of multi-well differential scanning fluorimetry experiments

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    74240_1.pdf (242.0Kb)
    Author(s)
    Wang, Conan K
    Weeratunga, Saroja K
    Pacheco, Chris M
    Hofmann, Andreas
    Griffith University Author(s)
    Hofmann, Andreas
    Wang, Conan K.
    Weeratunga, Saroja
    Pacheco Rivera, Chris
    Year published
    2012
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    Abstract
    Summary: Differential scanning fluorimetry (DSF) is a rapid technique that can be used in structural biology to study protein- ligand interactions. We have developed DMAN, a novel tool to analyse multi-well plate data obtained in DSF experiments. DMAN is easy to install and provides a user-friendly interface. Multi-well plate layouts can be designed by the user and experimental data can be annotated and analysed by DMAN according to the specified plate layout. Statistical tests for significance are performed automatically, and graphical tools are also provided to assist in data analysis. The modular concept of this ...
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    Summary: Differential scanning fluorimetry (DSF) is a rapid technique that can be used in structural biology to study protein- ligand interactions. We have developed DMAN, a novel tool to analyse multi-well plate data obtained in DSF experiments. DMAN is easy to install and provides a user-friendly interface. Multi-well plate layouts can be designed by the user and experimental data can be annotated and analysed by DMAN according to the specified plate layout. Statistical tests for significance are performed automatically, and graphical tools are also provided to assist in data analysis. The modular concept of this software will allow easy development of other multi-well plate analysis applications in the future. Availability and implementation: DMAN is implemented in Java to provide a cross-platform compatibility. It is freely available to academic users at http://www.structuralchemistry.org/pcsb/. To download DMAN, users will be asked for their name, institution and email address. A manual can also be downloaded from this site. Contact: conan.wang@griffith.edu.au; a.hofmann@griffith.edu.au
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    Journal Title
    Bioinformatics
    Volume
    28
    Issue
    3
    DOI
    https://doi.org/10.1093/bioinformatics/btr664
    Copyright Statement
    © 2012 Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Bioinformatics following peer review. The definitive publisher-authenticated version DMAN: a Java tool for analysis of multi-well differential scanning fluorimetry experiments, Bioinformatics, Volume 28 (3), 2012, Pages 439-440 is available online at: http://dx.doi.org/10.1093/bioinformatics/btr664
    Subject
    Mathematical sciences
    Biological sciences
    Structural biology (incl. macromolecular modelling)
    Information and computing sciences
    Publication URI
    http://hdl.handle.net/10072/46872
    Collection
    • Journal articles

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