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dc.contributor.authorCamp, Daviden_US
dc.contributor.authorDavis, Rohanen_US
dc.contributor.authorCampitelli, Marcen_US
dc.contributor.authorEbdon, Jamesen_US
dc.contributor.authorQuinn, Ronalden_US
dc.contributor.editorA. Douglas Kinghornen_US
dc.date.accessioned2017-05-03T11:15:20Z
dc.date.available2017-05-03T11:15:20Z
dc.date.issued2012en_US
dc.identifier.issn1520-6025en_US
dc.identifier.doi10.1021/np200687ven_US
dc.identifier.urihttp://hdl.handle.net/10072/46903
dc.description.abstractWhile natural products or their derivatives and mimics have contributed around 50% of current drugs, there has been no approach allowing front-loading of chemical space compliant with lead- and drug-like properties. The importance of physicochemical properties of molecules in the development of orally bioavailable drugs has been recognized. Classical natural product drug discovery has only been able to undertake this analysis retrospectively after compounds are isolated and structures elucidated. The present approach addresses front-loading of both extracts and subsequent fractions with desired physicochemical properties prior to screening for drug discovery. The physicochemical profiles of natural products active against two neglected disease targets, malaria and African trypanosomiasis, are presented based on this strategy. This approach can ensure timely development of natural product leads at a hitherto unachievable rate.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent203366 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherAmerican Chemical Societyen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom72en_US
dc.relation.ispartofpageto81en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalJournal of Natural Productsen_US
dc.relation.ispartofvolume75en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry not elsewhere classifieden_US
dc.subject.fieldofresearchcode030499en_US
dc.titleDrug-like Properties: Guiding Principles for the Design of Natural Product Librariesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightThis document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Natural Products, copyright 2012 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np200687v.en_US
gro.date.issued2015-07-30T23:06:40Z
gro.hasfulltextFull Text


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