Show simple item record

dc.contributor.authorCamp, David
dc.contributor.authorDavis, Rohan A
dc.contributor.authorCampitelli, Marc
dc.contributor.authorEbdon, James
dc.contributor.authorQuinn, Ronald J
dc.contributor.editorA. Douglas Kinghorn
dc.date.accessioned2017-05-03T11:15:20Z
dc.date.available2017-05-03T11:15:20Z
dc.date.issued2012
dc.identifier.issn0163-3864
dc.identifier.doi10.1021/np200687v
dc.identifier.urihttp://hdl.handle.net/10072/46903
dc.description.abstractWhile natural products or their derivatives and mimics have contributed around 50% of current drugs, there has been no approach allowing front-loading of chemical space compliant with lead- and drug-like properties. The importance of physicochemical properties of molecules in the development of orally bioavailable drugs has been recognized. Classical natural product drug discovery has only been able to undertake this analysis retrospectively after compounds are isolated and structures elucidated. The present approach addresses front-loading of both extracts and subsequent fractions with desired physicochemical properties prior to screening for drug discovery. The physicochemical profiles of natural products active against two neglected disease targets, malaria and African trypanosomiasis, are presented based on this strategy. This approach can ensure timely development of natural product leads at a hitherto unachievable rate.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent203366 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom72
dc.relation.ispartofpageto81
dc.relation.ispartofissue1
dc.relation.ispartofjournalJournal of Natural Products
dc.relation.ispartofvolume75
dc.rights.retentionY
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchMedicinal and biomolecular chemistry not elsewhere classified
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchTraditional, complementary and integrative medicine
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode340499
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode4208
dc.titleDrug-like Properties: Guiding Principles for the Design of Natural Product Libraries
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyrightThis document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Natural Products, copyright 2012 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np200687v.
gro.date.issued2015-07-30T23:06:40Z
gro.hasfulltextFull Text
gro.griffith.authorQuinn, Ronald J.
gro.griffith.authorDavis, Rohan A.


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record