Cyclic products of the Ugi reaction of aldehydo and keto carboxylic acids: chemoselective modification
Abstract
A method for the chemoselective reduction of Ugi-type lactam amides at the lactam carbonyl functionality with borane complexes has been developed. The novel reduction products can be further manipulated synthetically to yield various novel N- and C-terminally active unnatural amino acid building blocks.
Journal Title
Tetrahedron Letters
Volume
52
Issue
15
Copyright Statement
Copyright 2011 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Subject
Organic Chemical Synthesis