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  • Cyclic products of the Ugi reaction of aldehydo and keto carboxylic acids: chemoselective modification

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    Author(s)
    Tsaloev, Alan
    Ilyin, Alexei
    Tkachenko, Sergey
    Ivachtchenko, Alexandre
    Kravchenko, Dmitry
    Krasavin, Mikhail
    Griffith University Author(s)
    Krasavin, Mikhail
    Year published
    2011
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    Abstract
    A method for the chemoselective reduction of Ugi-type lactam amides at the lactam carbonyl functionality with borane complexes has been developed. The novel reduction products can be further manipulated synthetically to yield various novel N- and C-terminally active unnatural amino acid building blocks.A method for the chemoselective reduction of Ugi-type lactam amides at the lactam carbonyl functionality with borane complexes has been developed. The novel reduction products can be further manipulated synthetically to yield various novel N- and C-terminally active unnatural amino acid building blocks.
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    Journal Title
    Tetrahedron Letters
    Volume
    52
    Issue
    15
    DOI
    https://doi.org/10.1016/j.tetlet.2011.02.028
    Copyright Statement
    © 2011 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Organic Chemical Synthesis
    Medicinal and Biomolecular Chemistry
    Organic Chemistry
    Publication URI
    http://hdl.handle.net/10072/46955
    Collection
    • Journal articles

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