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  • Dihydro-resveratrol—A potent dietary polyphenol

    Author(s)
    A. Gakh, Andrei
    Anisimova, Natalia
    V. Kiselevsky, Mikhail
    V. Sadovnikov, Sergey
    N. Stankov, Ivan
    V. Yudin, Mikhail
    A. Rufanov, Konstantin
    Krasavin, Mikhail
    V. Sosnov, Andrey
    Griffith University Author(s)
    Krasavin, Mikhail
    Year published
    2010
    Metadata
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    Abstract
    Dihydro-resveratrol (dihydro-R), a prominent polyphenol component of red wine, has a profound proliferative effect on hormone-sensitive tumor cell lines such as breast cancer cell line MCF7. We found a significant increase in MCF7 tumor cells growth rates in the presence of picomolar concentrations of this compound. The proliferative effect of dihydro-R was not observed in cell lines that do not express hormone receptors (MDA-MB-231, BT-474, and ?-562).Dihydro-resveratrol (dihydro-R), a prominent polyphenol component of red wine, has a profound proliferative effect on hormone-sensitive tumor cell lines such as breast cancer cell line MCF7. We found a significant increase in MCF7 tumor cells growth rates in the presence of picomolar concentrations of this compound. The proliferative effect of dihydro-R was not observed in cell lines that do not express hormone receptors (MDA-MB-231, BT-474, and ?-562).
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    Journal Title
    Bioorganic & Medicinal Chemistry Letters
    Volume
    20
    Issue
    20
    DOI
    https://doi.org/10.1016/j.bmcl.2010.08.002
    Subject
    Biologically Active Molecules
    Medicinal and Biomolecular Chemistry
    Organic Chemistry
    Pharmacology and Pharmaceutical Sciences
    Publication URI
    http://hdl.handle.net/10072/46956
    Collection
    • Journal articles

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