The effect of ischaemic region shape on epicardial potential distributions in transient models of cardiac tissue
Abstract
Previous work on ischaemia during the ST segment has shown that the shape of the ischaemic region can signi cantly a ect the epicar- dial potential distribution at the surface of the heart. This numerical study compares the results from the steady state simulations with a more realistic transient model. The model consists of a slab of ven- tricular tissue with an ischaemic region at the centre resting on a blood bath. The transient bidomain equations were solved using a nite volume method for the spatial discretisation and a semi-implicit method for the time integration. Ischaemia is included by taking into account ...
View more >Previous work on ischaemia during the ST segment has shown that the shape of the ischaemic region can signi cantly a ect the epicar- dial potential distribution at the surface of the heart. This numerical study compares the results from the steady state simulations with a more realistic transient model. The model consists of a slab of ven- tricular tissue with an ischaemic region at the centre resting on a blood bath. The transient bidomain equations were solved using a nite volume method for the spatial discretisation and a semi-implicit method for the time integration. Ischaemia is included by taking into account three of the main physiological consequences which include hyperkalaemia, acidosis and anoxia. Results are obtained for three dif- ferent ischaemic region geometries (rectangular, cylindrical and semi- ellipsoidal).
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View more >Previous work on ischaemia during the ST segment has shown that the shape of the ischaemic region can signi cantly a ect the epicar- dial potential distribution at the surface of the heart. This numerical study compares the results from the steady state simulations with a more realistic transient model. The model consists of a slab of ven- tricular tissue with an ischaemic region at the centre resting on a blood bath. The transient bidomain equations were solved using a nite volume method for the spatial discretisation and a semi-implicit method for the time integration. Ischaemia is included by taking into account three of the main physiological consequences which include hyperkalaemia, acidosis and anoxia. Results are obtained for three dif- ferent ischaemic region geometries (rectangular, cylindrical and semi- ellipsoidal).
View less >
Conference Title
ANZIAM JOURNAL
Volume
53
Issue
SUPPL
Publisher URI
Copyright Statement
© 2011 Australian Mathematical Society. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the conference's website for access to the definitive, published version.
Subject
Mathematical sciences
Biological mathematics
Engineering