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dc.contributor.authorSohrabi, HRen_US
dc.contributor.authorBates, KAen_US
dc.contributor.authorWeinborn, MGen_US
dc.contributor.authorJohnston, Amyen_US
dc.contributor.authorBahramian, Aen_US
dc.contributor.authorTaddei, Ken_US
dc.contributor.authorLaws, SMen_US
dc.contributor.authorRodrigues, Men_US
dc.contributor.authorMoricci, Men_US
dc.contributor.authorHoward, Men_US
dc.contributor.authorMartins, Gen_US
dc.contributor.authorMackay-Sim, Alanen_US
dc.contributor.authorGandy, SEen_US
dc.contributor.authorMartins, RNen_US
dc.contributor.editorJulio Licinioen_US
dc.date.accessioned2017-05-03T14:27:35Z
dc.date.available2017-05-03T14:27:35Z
dc.date.issued2012en_US
dc.date.modified2013-06-03T00:53:29Z
dc.identifier.issn2158-3188en_US
dc.identifier.doi10.1038/tp.2012.43en_US
dc.identifier.urihttp://hdl.handle.net/10072/47110
dc.description.abstractThe presence of olfactory dysfunction in individuals at higher risk of Alzheimer's disease has significant diagnostic and screening implications for preventive and ameliorative drug trials. Olfactory threshold, discrimination and identification can be reliably recorded in the early stages of neurodegenerative diseases. The current study has examined the ability of various olfactory functions in predicting cognitive decline in a community-dwelling sample. A group of 308 participants, aged 46-86 years old, were recruited for this study. After 3 years of follow-up, participants were divided into cognitively declined and non-declined groups based on their performance on a neuropsychological battery. Assessment of olfactory functions using the Sniffin' Sticks battery indicated that, contrary to previous findings, olfactory discrimination, but not olfactory identification, significantly predicted subsequent cognitive decline (odds ratio=0.869; P<0.05; 95% confidence interval=0.764-0.988). The current study findings confirm previously reported associations between olfactory and cognitive functions, and indicate that impairment in olfactory discrimination can predict future cognitive decline. These findings further our current understanding of the association between cognition and olfaction, and support olfactory assessment in screening those at higher risk of dementia.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherNature Publishing Groupen_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrome118-1en_US
dc.relation.ispartofpagetoe118-7en_US
dc.relation.ispartofjournalTranslational Psychiatryen_US
dc.relation.ispartofvolume2en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchSensory Systemsen_US
dc.subject.fieldofresearchcode110906en_US
dc.titleOlfactory discrimination predicts cognitive decline among community-dwelling older adultsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2012
gro.hasfulltextNo Full Text


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