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  • Low dosage promethazine and loratadine negatively affect neuromotor function

    Author(s)
    Kavanagh, Justin J
    Grant, Gary D
    Anoopkumar-Dukie, Shailendra
    Griffith University Author(s)
    Kavanagh, Justin J.
    Grant, Gary D.
    Anoopkumar-Dukie, Shailendra
    Year published
    2012
    Metadata
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    Abstract
    Abstract OBJECTIVES: Determine how the sedating antihistamine promethazine and non-sedating antihistamine loratadine at a dose of 10mg influence voluntary and involuntary motor processes in the hours following ingestion and the morning after ingestion. METHODS: Eight healthy young adults were recruited into a human double-blind, placebo-controlled, three-way crossover study. Neuromotor function was examined using a battery of controlled reaction time, postural tremor, and heart rate variability measures. Neuromotor function was assessed 4 times for each of the promethazine, loratadine and placebo interventions; ...
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    Abstract OBJECTIVES: Determine how the sedating antihistamine promethazine and non-sedating antihistamine loratadine at a dose of 10mg influence voluntary and involuntary motor processes in the hours following ingestion and the morning after ingestion. METHODS: Eight healthy young adults were recruited into a human double-blind, placebo-controlled, three-way crossover study. Neuromotor function was examined using a battery of controlled reaction time, postural tremor, and heart rate variability measures. Neuromotor function was assessed 4 times for each of the promethazine, loratadine and placebo interventions; pre-ingestion, 1h post-ingestion, 2h post-ingestion, and the following day. RESULTS: Self-perceived levels of drowsiness increased only after ingestion of promethazine. However, both antihistamines had negative effects on simple reaction time, choice reaction time, the RMS and peak power amplitude of postural tremor, and autonomic cardiac regulation. CONCLUSIONS: The presence of selective neuromotor deficits following ingestion of promethazine and loratadine suggest that sedating and non-sedating antihistamines alter neuromotor function. It is possible that the H(1) antagonists used in this study have antimuscarinic effects, which may impact on the central dopaminergic system that plays a role in modulating several CNS processes associated with movement. SIGNIFICANCE: Antihistamines are one of the most commonly procured over-the-counter medications. The current study suggests that taking non-sedating antihistamines to avoid the adverse drug reaction of drowsiness may not avoid unwanted motor control side-effects.
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    Journal Title
    Clinical Neurophysiology
    Volume
    123
    Issue
    4
    DOI
    https://doi.org/10.1016/j.clinph.2011.07.046
    Subject
    Clinical Sciences not elsewhere classified
    Engineering
    Medical and Health Sciences
    Psychology and Cognitive Sciences
    Publication URI
    http://hdl.handle.net/10072/47253
    Collection
    • Journal articles

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