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dc.contributor.authorGijsen, Hanel Sadie-Vanen_US
dc.contributor.authorSmith, Wayneen_US
dc.contributor.authorDu Toit, Eugeneen_US
dc.contributor.authorMichie, Johnen_US
dc.contributor.authorHough, F.en_US
dc.contributor.authorFerris, William Franken_US
dc.date.accessioned2017-05-03T15:31:46Z
dc.date.available2017-05-03T15:31:46Z
dc.date.issued2012en_US
dc.date.modified2013-06-03T03:36:30Z
dc.identifier.issn03037207en_US
dc.identifier.doi10.1016/j.mce.2011.07.030en_US
dc.identifier.urihttp://hdl.handle.net/10072/47325
dc.description.abstractAdipose-derived stromal cells (ADSCs) can be differentiated in vitro into several mesenchyme-derived cell types. We had previously described depot-specific differences in the adipocyte differentiation of ADSCs, and consequently we hypothesized that there may also be depot-specific differences in osteoblast differentiation of ADSCs. For this study, the osteoblast differentiation potential of rat subcutaneous ADSCs (scADSCs) and perirenal visceral ADSCs (pvADSCs) was compared. Osteoblast differentiation media (OM) induced markers of the osteoblastic phenotype in scADSCs, but not in pvADSCs. ADSCs harvested from rats with diet-induced visceral obesity (DIO) exhibited reduced osteoinduction, compared to lean controls, but adipocyte differentiation was not affected. Expression of the pro-osteogenic transcription factor Msx2 was significantly higher in naﶥ scADSCs from lean and DIO rats than in pvADSCs. Our findings indicate that ADSCs from different anatomical sites are uniquely pre-programmed in vivo in a depot-specific manner, and that diet-induced metabolic disturbances translate into reduced osteoblast differentiation of ADSCs.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.publisher.placeIrelanden_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom55en_US
dc.relation.ispartofpageto66en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalMolecular and Cellular Endocrinologyen_US
dc.relation.ispartofvolume348en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchCell Physiologyen_US
dc.subject.fieldofresearchcode111601en_US
dc.titleDepot-specific and hypercaloric diet-induced effects on the osteoblast and adipocyte differentiation potential of adipose-derived stromal cellsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2012
gro.hasfulltextNo Full Text


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