Show simple item record

dc.contributor.authorWillems, Lauraen_US
dc.contributor.authorZatta, Amandaen_US
dc.contributor.authorHolmgren, Kirstyen_US
dc.contributor.authorAshton, Kevinen_US
dc.contributor.authorHeadrick, Johnen_US
dc.date.accessioned2017-04-24T08:09:06Z
dc.date.available2017-04-24T08:09:06Z
dc.date.issued2005en_US
dc.identifier.issn00222828en_US
dc.identifier.doi10.1016/j.yjmcc.2004.09.014en_US
dc.identifier.urihttp://hdl.handle.net/10072/4734
dc.description.abstractAging is associated with reduced tolerance to ischemic insult, and genesis of this intolerant phenotype is poorly understood. We characterized effects of aging and gender on cardiovascular function and cell damage during 20 min ischemia and 60 min reperfusion in isolated hearts from young adult (2-4 months), mature adult (8 months), middle-aged (12 months), aged (18 months), and senescent (24-28 months) C57/Bl6 mice. Aging substantially impaired recovery of ventricular contractility, with this change primarily evident within 12 months of age. In males ventricular developed pressure recovered to 72 ᠸ mmHg in young hearts vs. only 44 ᠷ, 30 ᠳ, 24 ᠵ, and 27 ᠴ mmHg in mature, middle-aged, aged and senescent hearts, respectively. This pattern was largely due to worsened diastolic dysfunction. Coronary flow recovered to below pre-ischemic levels in all ages, correlating with contractile recovery. However, coronary dysfunction (impaired responses to 2-chloroadenosine and ADP) was unaltered by senescence. Lactate dehydrogenase (LDH) loss, a marker for oncosis, increased to middle-age (approximately twofold), then fell with further aging to a value no longer different from that in young adult hearts. Similar patterns of change were observed in female hearts, although LDH efflux was significantly lower in mature adult and middle-aged female vs. male hearts, with functional tolerance also tending to be greater at these ages (though not achieving significance). Overall, our data reveal age-related ischemic intolerance develops well before senescence, being primarily evident by "middle-age". Phenotypic changes appear selective for myocardial vs. vascular injury, and functional vs. oncotic injury. Similar changes occur in males and females, though there is evidence of a protected phenotype in mature to middle-aged female vs. male hearts.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.publisher.placeLondon, UKen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom245en_US
dc.relation.ispartofpageto256en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalJournal of Molecular and Cellular Cardiologyen_US
dc.relation.ispartofvolume38en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchcode320603en_US
dc.titleAge-related changes in ischemic tolerance in male and female mouse heartsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2015-05-05T05:03:57Z
gro.hasfulltextNo Full Text


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record