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  • Apoptosis and MicroRNA Aberrations in Cancer

    Author(s)
    Li, Chun
    Hashimi, Saeed M
    Good, David A
    Cao, Siyu
    Duan, Wei
    Plummer, Prue N
    Mellick, Albert S
    Wei, Ming Q
    Griffith University Author(s)
    Good, David A.
    Mellick, Albert S.
    Hashimi, Saeed M.
    Cao, Siyu
    Li, Chun
    Plummer, Prue N.
    Wei, Ming Q.
    Year published
    2012
    Metadata
    Show full item record
    Abstract
    Summary 1. Carcinogenesis arises from the malfunction of genes that control cell growth and division. Therefore, the most effective method of hindering tumourigenesis is to induce the death of immortalized cancer cells. 2. Apoptosis or programmed cell death has shown the most promises in impairing cancer growth. A variety of proteins is involved in the regulation of apoptosis and the malfunction of any these regulators may cause cell proliferation. 3. The microRNAs have been shown to play a central role in the regulation of the cell cycle, including apoptosis. The microRNAs are involved in post-transcriptional ...
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    Summary 1. Carcinogenesis arises from the malfunction of genes that control cell growth and division. Therefore, the most effective method of hindering tumourigenesis is to induce the death of immortalized cancer cells. 2. Apoptosis or programmed cell death has shown the most promises in impairing cancer growth. A variety of proteins is involved in the regulation of apoptosis and the malfunction of any these regulators may cause cell proliferation. 3. The microRNAs have been shown to play a central role in the regulation of the cell cycle, including apoptosis. The microRNAs are involved in post-transcriptional gene suppression and have been implicated in the regulation of cell differentiation and development. 4. Aberrations in the microRNA regulation of apoptosis lead to tumourigenesis. 5. The present review assesses the current knowledge of apoptotic regulation in cancer and the effect of microRNA aberrations in tumourigenesis.
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    Journal Title
    Clinical and Experimental Pharmacology & Physiology
    Volume
    39
    Issue
    8
    DOI
    https://doi.org/10.1111/j.1440-1681.2012.05700.x
    Subject
    Biochemistry and Cell Biology not elsewhere classified
    Physiology
    Pharmacology and Pharmaceutical Sciences
    Medical Physiology
    Publication URI
    http://hdl.handle.net/10072/47510
    Collection
    • Journal articles

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