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dc.contributor.authorLi, Chun
dc.contributor.authorHashimi, Saeed M
dc.contributor.authorGood, David A
dc.contributor.authorCao, Siyu
dc.contributor.authorDuan, Wei
dc.contributor.authorPlummer, Prue N
dc.contributor.authorMellick, Albert S
dc.contributor.authorWei, Ming Q
dc.date.accessioned2017-05-03T14:06:25Z
dc.date.available2017-05-03T14:06:25Z
dc.date.issued2012
dc.date.modified2013-06-07T04:23:23Z
dc.identifier.issn0305-1870
dc.identifier.doi10.1111/j.1440-1681.2012.05700.x
dc.identifier.urihttp://hdl.handle.net/10072/47510
dc.description.abstractSummary 1. Carcinogenesis arises from the malfunction of genes that control cell growth and division. Therefore, the most effective method of hindering tumourigenesis is to induce the death of immortalized cancer cells. 2. Apoptosis or programmed cell death has shown the most promises in impairing cancer growth. A variety of proteins is involved in the regulation of apoptosis and the malfunction of any these regulators may cause cell proliferation. 3. The microRNAs have been shown to play a central role in the regulation of the cell cycle, including apoptosis. The microRNAs are involved in post-transcriptional gene suppression and have been implicated in the regulation of cell differentiation and development. 4. Aberrations in the microRNA regulation of apoptosis lead to tumourigenesis. 5. The present review assesses the current knowledge of apoptotic regulation in cancer and the effect of microRNA aberrations in tumourigenesis.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoen_US
dc.publisherWiley-Blackwell Publishing Asia
dc.publisher.placeAustralia
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom739
dc.relation.ispartofpageto746
dc.relation.ispartofissue8
dc.relation.ispartofjournalClinical and Experimental Pharmacology & Physiology
dc.relation.ispartofvolume39
dc.rights.retentionY
dc.subject.fieldofresearchBiochemistry and Cell Biology not elsewhere classified
dc.subject.fieldofresearchPhysiology
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchMedical Physiology
dc.subject.fieldofresearchcode060199
dc.subject.fieldofresearchcode0606
dc.subject.fieldofresearchcode1115
dc.subject.fieldofresearchcode1116
dc.titleApoptosis and MicroRNA Aberrations in Cancer
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.date.issued2012
gro.hasfulltextNo Full Text
gro.griffith.authorGood, David A.
gro.griffith.authorMellick, Albert S.
gro.griffith.authorHashimi, Saeed M.
gro.griffith.authorCao, Siyu
gro.griffith.authorLi, Chun
gro.griffith.authorPlummer, Prue N.
gro.griffith.authorWei, Ming Q.


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