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dc.contributor.authorStuart, Shani
dc.contributor.authorCox, Hannah
dc.contributor.authorLea, Rodney
dc.contributor.authorGriffiths, Lyn
dc.date.accessioned2017-05-03T11:39:28Z
dc.date.available2017-05-03T11:39:28Z
dc.date.issued2012
dc.date.modified2013-06-17T02:36:12Z
dc.identifier.issn00178748
dc.identifier.doi10.1111/j.1526-4610.2012.02106.x
dc.identifier.urihttp://hdl.handle.net/10072/47532
dc.description.abstractMigraine is a common neurological disorder and is characterized by debilitating head pain and an assortment of additional symptoms which can include nausea, emesis, photophobia, phonophobia, and occasionally, visual sensory disturbances. A number of genes have been implicated in the pathogenesis of this disease, including genes involved in regulating the vascular system. Of particular importance are the methylenetetrahydrofolate reductase (MTHFR) gene and the role it plays in migraine with aura. Migraine with aura has previously been shown to have a significant comorbidity with stroke, making the vascular class of genes a priority for migraine studies. In this report, we outline the importance of the MTHFR gene in migraine and also discuss the use of a genetic isolate to investigate MTHFR genetic variants. From this study, 3 MTHFR single nucleotide polymorphisms showing association with migraine in the Norfolk Island population have been identified, thus reinforcing the potential role of MTHFR in migraine susceptibility. Further studies will continue to build a gene profile of variants involved in the complex disease migraine and improve understanding of the underlying genetic causes of this disorder.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent184660 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrom515
dc.relation.ispartofpageto520
dc.relation.ispartofissue3
dc.relation.ispartofjournalHeadache
dc.relation.ispartofvolume52
dc.rights.retentionY
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode119999
dc.subject.fieldofresearchcode1103
dc.titleThe role of the MTHFR gene in migraine
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.rights.copyright© 2012 American Headache Society. This is the pre-peer reviewed version of the following article: The role of the MTHFR gene in migraine, Headache, Vol. 52(3), 2012, pp. 515-520, which has been published in final form at http://dx.doi.org/10.1111/j.1526-4610.2012.02106.x.
gro.date.issued2012
gro.hasfulltextFull Text
gro.griffith.authorGriffiths, Lyn
gro.griffith.authorLea, Rodney A.
gro.griffith.authorCox, Hannah
gro.griffith.authorStuart, Shani


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