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dc.contributor.authorSanthakumar, Abishek
dc.contributor.authorLinden, M.
dc.contributor.authorSingh, Indu
dc.date.accessioned2019-01-07T01:31:02Z
dc.date.available2019-01-07T01:31:02Z
dc.date.issued2012
dc.date.modified2013-06-11T04:19:32Z
dc.identifier.issn2162-8440
dc.identifier.doi10.5923/j.fph.20120202.10
dc.identifier.urihttp://hdl.handle.net/10072/47572
dc.description.abstractTaurine, 2-aminoethanesulphonic acid is a common ingredient of energy drinks which is very popular with young adults. Taurine in energy drinks is known to enhance muscular performance in athletes. However, caffeine in high concentrations as found in most energy drinks have also been implicated to play an adverse role leading to cardiovascular diseases (CVD). Hyper activation of platelets is one of the major risk factors of CVD. The aim of the study was to evaluate effect of taurine alone on platelet aggregation and activation of platelet surface antigens by flowcytometry. It is hypothesized that taurine's antioxidant property would inhibit platelet activity. Twelve healthy, male and female, volunteers aged 20-60 years were recruited for this study. A statistically significant inhibition of platelet aggregation was observed upon stimulation with agonists adenosine diphosphate (ADP), collagen and arachidonic acid (AA) (p<0.05). The platelet surface expression of PAC1 and p-selectin induced by all three agonists also decreased compared to baseline but was not statistically significant. In conclusion this study demonstrated that taurine at a concentration of (energy drinks contain approximately 31mM taurine), inhibits the platelet hyperactivity in platelet rich plasma. Further mechanistic and interventional studies are required to examine the pathway involved in support of beneficial role of taurine in prevention of risk factors leading to cardiovascular disorders. Synergistic effect of varying doses of caffeine and taurine will also be evaluated to obtain most effective and protective doses for energy drinks.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent247161 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherScientific & Academic Publishing
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrom58
dc.relation.ispartofpageto64
dc.relation.ispartofissue2
dc.relation.ispartofjournalFood and Public Health
dc.relation.ispartofvolume2
dc.rights.retentionY
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchNutrition and Dietetics
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode119999
dc.subject.fieldofresearchcode1111
dc.subject.fieldofresearchcode1117
dc.titleTaurine in Lower Concentration Attenuates Platelet Activity
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.rights.copyright© 2012 Scientific & Academic Publishing. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2012
gro.hasfulltextFull Text
gro.griffith.authorSingh, Indu
gro.griffith.authorSanthakumar, Abishek B.


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