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dc.contributor.authorLoughrey, Bradley T
dc.contributor.authorCunning, Benjamin V
dc.contributor.authorHealy, Peter C
dc.contributor.authorBrown, Christopher L
dc.contributor.authorParsons, Peter G
dc.contributor.authorWilliams, Michael L
dc.date.accessioned2017-05-03T13:05:10Z
dc.date.available2017-05-03T13:05:10Z
dc.date.issued2012
dc.date.modified2013-06-03T04:15:29Z
dc.identifier.issn1861-4728
dc.identifier.doi10.1002/asia.201100637
dc.identifier.urihttp://hdl.handle.net/10072/47599
dc.description.abstractA structurally diverse range of lipophilic, cationic ?6-arene ?5-cyclopentadienyl (?5-Cp*) full-sandwich complexes of ruthenium(II) have been prepared and structurally characterized by Fourier-transform IR and NMR spectroscopy, electrospray mass spectrometry, and elemental microanalyses. Computational experiments incorporating the Hartree-Fock theory and the second-order M謬er-Plesset perturbation theory predict each complex to possess a uniform d+ electrostatic potential, with the cationic charge of the [RuCp*]+ moiety completely delocalizing throughout the molecular structure of each metallocene. In vitro cytotoxicity studies demonstrate these delocalized lipophilic cations to be potent growth inhibitors of eleven unique tumorigenic cell lines, while exhibiting significantly lower levels of toxicity towards both a normal human fibroblast and a mouse macrophage cell line. Single-crystal X-ray structural determinations are additionally reported for five complexes, [Ru(?6-C6H5(CH2)2CH3)(?5-C5(CH3)5)]BPh4, [Ru(?6-C6H5CO2CH2CH3)(?5-C5(CH3)5)]BF4, [Ru(?6-C10H8)(?5-C5(CH3)5)]BPh4, [Ru(?6-C14H10)(?5-C5(CH3)5)]BPh4, and [Ru(?6-C16H10)(?5-C5(CH3)5)]BPh4
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-VCH
dc.publisher.placeGermany
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom112
dc.relation.ispartofpageto121
dc.relation.ispartofissue1
dc.relation.ispartofjournalChemistry - An Asian Journal
dc.relation.ispartofvolume7
dc.rights.retentionY
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchBiologically active molecules
dc.subject.fieldofresearchOrganometallic chemistry
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode340401
dc.subject.fieldofresearchcode340209
dc.titleSelective, Cytotoxic Organoruthenium(II) Full-Sandwich Complexes: A Structural, Computational and In Vitro Biological Study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2012
gro.hasfulltextNo Full Text
gro.griffith.authorHealy, Peter C.


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