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dc.contributor.authorHakimizadeh, Elham
dc.contributor.authorArababadi, Mohammad Kazemi
dc.contributor.authorHassanshahi, Gholamhossein
dc.contributor.authorAhmadabadi, Behzad Nasiri
dc.contributor.authorHakimi, Hamid
dc.contributor.authorRezaeian, Mohsen
dc.contributor.authorSalehabadi, Vajihe Akbarpour
dc.contributor.authorYousefidaredor, Hassan
dc.contributor.authorAbousaidi, Hamid
dc.contributor.authorKennedy, Derek
dc.date.accessioned2017-05-03T11:12:35Z
dc.date.available2017-05-03T11:12:35Z
dc.date.issued2012
dc.date.modified2014-08-13T23:52:53Z
dc.identifier.issn1433-6510
dc.identifier.urihttp://hdl.handle.net/10072/47602
dc.description.abstractBackground: Cytokines are considered important factors for the pathogenesis of asthma as they play a key role in the regulation of immune responses. The aim of this study was to investigate the association between this disease and polymorphisms in the -592 region of the IL-10 gene. METHODS: This study was carried out on 100 asthmatic patients and 100 healthy controls. PCR-RFLP was applied to examine the polymorphisms in the -592 region of the IL-10 gene. RESULTS: Our results showed a significant difference between patients and controls in terms of genotypes and alleles of the -592 region of the IL-10 gene. CONCLUSIONS: According to our results, it can be concluded that the IL-10 promoter polymorphisms may play a crucial role in the pathogenesis of asthma.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent208433 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherClinical Laboratory Publications
dc.publisher.placeGermany
dc.publisher.urihttp://www.clin-lab-publications.com/issue/80
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom267
dc.relation.ispartofpageto271
dc.relation.ispartofissue3-4
dc.relation.ispartofjournalClinical Laboratory
dc.relation.ispartofvolume58
dc.rights.retentionY
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchMedical genetics (excl. cancer genetics)
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode320213
dc.titleAssociation of -592 Region of IL-10 Polymorphisms with Asthma in South-Eastern Iranian Patients
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2012 Clinical Laboratory Publications. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2012
gro.hasfulltextFull Text
gro.griffith.authorKennedy, Derek D.


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