Show simple item record

dc.contributor.authorLill, Christinaen_US
dc.contributor.authorLiu, Tianen_US
dc.contributor.authorSchjeide, Brit-Marenen_US
dc.contributor.authorRoehr, Johannesen_US
dc.contributor.authorAkkad, Dennisen_US
dc.contributor.authorDamotte, Vincenten_US
dc.contributor.authorAlcina, Antonioen_US
dc.contributor.authorOrtiz, Miguelen_US
dc.contributor.authorArroyo, Rafaen_US
dc.contributor.authorde Lapuente, Aitzkoa Lopezen_US
dc.contributor.authorBlaschke, Paulen_US
dc.contributor.authorWinkelmann, Alexanderen_US
dc.contributor.authorGerdes, Lisa-Annen_US
dc.contributor.authorLuessi, Felixen_US
dc.contributor.authorFernandez, Oscaren_US
dc.contributor.authorIzquierdo, Guillermoen_US
dc.contributor.authorAntiguedad, Alfredoen_US
dc.contributor.authorHoffjan, Sabineen_US
dc.contributor.authorCournu-Rebeix, Isabelleen_US
dc.contributor.authorGromöller, Silvanaen_US
dc.contributor.authorFaber, Hansen_US
dc.contributor.authorLiebsch, Mariaen_US
dc.contributor.authorMeissner, Estheren_US
dc.contributor.authorChanvillard, Coralieen_US
dc.contributor.authorTouze, Emmanuelen_US
dc.contributor.authorPico, Fernandoen_US
dc.contributor.authorCorcia, Philippeen_US
dc.contributor.authorBahlo, Melanieen_US
dc.contributor.authorBooth, Daviden_US
dc.contributor.authorBroadley, Simonen_US
dc.contributor.authorBrown, Matthewen_US
dc.contributor.authorBrowning, Brianen_US
dc.contributor.authorBrowning, Sharonen_US
dc.contributor.authorButzkueven, Helmuten_US
dc.contributor.authorCarroll, Williamen_US
dc.contributor.authorCox, Mathewen_US
dc.contributor.authorChapman, Caronen_US
dc.contributor.authorClarke, Glynnisen_US
dc.contributor.authorDanoy, Patricken_US
dc.contributor.authorDrysdale, Karenen_US
dc.contributor.authorField, Judithen_US
dc.contributor.authorFoote, Simonen_US
dc.contributor.authorGreer, Judithen_US
dc.contributor.authorGriffiths, Lynen_US
dc.contributor.authorHadler, Johannaen_US
dc.contributor.authorJensen, Cathyen_US
dc.contributor.authorJohnson, Lauraen_US
dc.contributor.authorKermode, Allanen_US
dc.contributor.authorHeard, Roberten_US
dc.contributor.authorKilpatrick, Trevoren_US
dc.contributor.authorScott, Jeanette Lechner-en_US
dc.contributor.authorMarriott, Marken_US
dc.contributor.authorMason, Deborahen_US
dc.contributor.authorMoscato, Pabloen_US
dc.contributor.authorPender, Michaelen_US
dc.contributor.authorPerreau, Victoriaen_US
dc.contributor.authorRubio, Justinen_US
dc.contributor.authorScott, Rodneyen_US
dc.contributor.authorSlee, Marken_US
dc.contributor.authorStankovich, Jimen_US
dc.contributor.authorStewart, Graemeen_US
dc.contributor.authorTajouri, Lotfien_US
dc.contributor.authorTaylor, Bruceen_US
dc.contributor.authorWiley, Jamesen_US
dc.contributor.authorWilkins, Ellaen_US
dc.contributor.authorDörner, Thomasen_US
dc.contributor.authorSteinhagen-Thiessen, Elisabethen_US
dc.contributor.authorBaeckman, Larsen_US
dc.contributor.authorHeekeren, Haukeen_US
dc.contributor.authorLi, Shu-Chenen_US
dc.contributor.authorLindenberger, Ulmanen_US
dc.contributor.authorChan, Andrewen_US
dc.contributor.authorHartung, Hans- Peteren_US
dc.contributor.authorAktas, Orhanen_US
dc.contributor.authorLohse, Peteren_US
dc.contributor.authorKümpfel, Taniaen_US
dc.contributor.authorKubisch, Christianen_US
dc.contributor.authorEpplen, Joergen_US
dc.contributor.authorZettl, Uween_US
dc.contributor.authorFontaine, Bertranden_US
dc.contributor.authorVandenbroeck, Koenen_US
dc.contributor.authorMatesanz, Fuencislaen_US
dc.contributor.authorUrcelay, Elenaen_US
dc.contributor.authorBertram, Larsen_US
dc.contributor.authorZipp, Fraukeen_US
dc.date.accessioned2017-05-03T14:35:13Z
dc.date.available2017-05-03T14:35:13Z
dc.date.issued2012en_US
dc.date.modified2013-06-18T00:03:55Z
dc.identifier.issn14686244en_US
dc.identifier.doi10.1136/jmedgenet-2012-101175en_US
dc.identifier.urihttp://hdl.handle.net/10072/47633
dc.description.abstractBackground: Single nucleotide polymorphisms (SNPs) rs429358 (e4) and rs7412 (e2), both invoking changes in the amino-acid sequence of the apolipoprotein E (APOE) gene, have previously been tested for association with multiple sclerosis (MS) risk. However, none of these studies was sufficiently powered to detect modest effect sizes at acceptable type-I error rates. As both SNPs are only imperfectly captured on commonly used microarray genotyping platforms, their evaluation in the context of genome-wide association studies has been hindered until recently. Methods: We genotyped 12 740 subjects hitherto not studied for their APOE status, imputed raw genotype data from 8739 subjects from five independent genomewide association studies datasets using the most recent high-resolution reference panels, and extracted genotype data for 8265 subjects from previous candidate gene assessments. Results: Despite sufficient power to detect associations at genome-wide significance thresholds across a range of ORs, our analyses did not support a role of rs429358 or rs7412 on MS susceptibility. This included meta-analyses of the combined data across 13 913 MS cases and 15 831 controls (OR=0.95, p=0.259, and OR 1.07, p=0.0569, for rs429358 and rs7412, respectively). Conclusion: Given the large sample size of our analyses, it is unlikely that the two APOE missense SNPs studied here exert any relevant effects on MS susceptibility.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent235906 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherBMJ Publishing Groupen_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom558en_US
dc.relation.ispartofpageto562en_US
dc.relation.ispartofissue9en_US
dc.relation.ispartofjournalJournal of Medical Geneticsen_US
dc.relation.ispartofvolume49en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchCentral Nervous Systemen_US
dc.subject.fieldofresearchcode110903en_US
dc.titleClosing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjectsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright remains with the authors 2012. The attached file is reproduced here in accordance with the copyright policy of the publisher. For information about this journal please refer to the journal’s website or contact the authors.en_US
gro.date.issued2012
gro.hasfulltextFull Text


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record