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dc.contributor.authorCarey, Alisonen_US
dc.contributor.authorTan, CKen_US
dc.contributor.authorUlett, Glenen_US
dc.date.accessioned2017-05-03T15:53:00Z
dc.date.available2017-05-03T15:53:00Z
dc.date.issued2012en_US
dc.date.modified2013-08-29T22:59:17Z
dc.identifier.issn21623996en_US
dc.identifier.doi10.4161/jkst.19918en_US
dc.identifier.urihttp://hdl.handle.net/10072/47639
dc.description.abstractGeneration of effective immune responses against pathogenic microbes depends on a fine balance between pro- and antiinflammatory responses. Interleukin-10 (IL-10) is essential in regulating this balance and has garnered renewed interest recently as a modulator of the response to infection at the JAK-STAT signaling axis of host responses. Here, we examine how IL-10 functions as the 'master regulator' of immune responses through JAK-STAT, and provide a perspective from recent insights on bacterial, protozoan, and viral infection model systems. Pattern recognition and subsequent molecular events that drive activation of IL-10-associated JAK-STAT circuitry are reviewed and the implications for microbial pathogenesis are discussed.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent407315 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherLandes Bioscienceen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationYen_US
dc.relation.ispartofpagefrom1en_US
dc.relation.ispartofpageto9en_US
dc.relation.ispartofissue3en_US
dc.relation.ispartofjournalJAK-STATen_US
dc.relation.ispartofvolume1en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchMedical Microbiology not elsewhere classifieden_US
dc.subject.fieldofresearchInnate Immunityen_US
dc.subject.fieldofresearchcode110899en_US
dc.subject.fieldofresearchcode110707en_US
dc.titleInfection-induced IL-10 and JAK-STAT: A review of the molecular circuitry controlling immune hyperactivity in response to pathogenic microbesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Medical Scienceen_US
gro.rights.copyrightCopyright remains with the author[s] 2012. This is the author-manuscript version of this paper. It is posted here with permission of the copyright owner[s] for your personal use only. No further distribution permitted. For information about this journal please refer to the journal’s website or contact the author[s].en_US
gro.date.issued2012
gro.hasfulltextFull Text


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