Show simple item record

dc.contributor.authorPhung, Dungen_US
dc.contributor.authorConnell, Desen_US
dc.contributor.authorMiller, Gregen_US
dc.contributor.authorHodge, Maryen_US
dc.contributor.authorPatel, Renuen_US
dc.contributor.authorCheng, Ronen_US
dc.contributor.authorAbeyewardene, Manelen_US
dc.contributor.authorChu, Cordiaen_US
dc.date.accessioned2017-05-03T11:16:08Z
dc.date.available2017-05-03T11:16:08Z
dc.date.issued2012en_US
dc.date.modified2013-06-03T04:57:07Z
dc.identifier.issn00456535en_US
dc.identifier.doi10.1016/j.chemosphere.2011.11.075en_US
dc.identifier.urihttp://hdl.handle.net/10072/47665
dc.description.abstractChlorpyrifos is the most common organophosphate insecticide registered for use in Vietnam and is widely used in agriculture, particularly rice farming. However, chlorpyrifos exposure to and adverse effects on farmers has not been evaluated. In this study, biological monitoring of chlorpyrifos exposure in a group of rice farmers was conducted after a typical application event using back-pack spraying. Urine samples (24 h) were collected from the rice farmers before and post insecticide application. Samples were analysed for 3,5,6-trichloropyridinol (TCP), the major urinary metabolite of chlorpyrifos, using an enzymatic pre-treatment before extraction followed by HPLC-MS/MS. Absorbed Daily Dose (ADD) of chlorpyrifos for farmers were then estimated from urinary TCP levels, expressed as lg g 1 creatinine. The analytical method for urinary TCP had a low detection limit (0.6 lg L 1), acceptable recovery values (80-114%), and low relative percentage differences in duplicate and repeated samples. Post-application chlorpyrifos ADD of farmers varied from 0.4 to 94.2 lg kg 1 (body weight) d 1 with a mean of 19.4 lg kg 1 d 1 which was approximately 80-fold higher than the mean baseline exposure level (0.24 lg kg 1 d 1). Hazard Quotients (ratio of the mean ADD for rice farmers to acute oral reference dose) calculated using acute oral reference doses recommended by United States and Australian agencies varied from 2.1 (Australian NRA), 4.2 (US EPA) to 6.9 (ATSDR). Biological monitoring using HPLC-MS/MS analysis of urinary TCP (24 h) was found to be an effective method for measuring chlorpyrifos exposure among farmers. This case study found that Vietnamese rice farmers had relatively high exposures to chlorpyrifos after application, which were likely to have adverse health effects.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent511702 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom294en_US
dc.relation.ispartofpageto300en_US
dc.relation.ispartofissue4en_US
dc.relation.ispartofjournalChemosphereen_US
dc.relation.ispartofvolume87en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchcode321201en_US
dc.titleBiological monitoring of chlorpyrifos exposure to rice farmers in Vietnamen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Sciences, Griffith School of Environmenten_US
gro.rights.copyrightCopyright 2012 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.en_US
gro.date.issued2012
gro.hasfulltextFull Text


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record