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  • Alcohol pharmacokinetics and risk-taking behaviour following exercise-induced dehydration

    Author(s)
    Irwin, Christopher
    Goodwin, Alison
    Leveritt, Michael
    Davey, Andrew K
    Desbrow, Ben
    Griffith University Author(s)
    Desbrow, Ben
    Leveritt, Michael
    Irwin, Chris
    Goodwin, Alison C.
    Davey, Andrew
    Irwin, Chris G.
    Year published
    2012
    Metadata
    Show full item record
    Abstract
    This study investigated the influence of exercise-induced dehydration on alcohol pharmacokinetics, subjective ratings of impairment, and risk-taking behaviours. Twelve male volunteers participated in 3 experimental trials completed in a randomised cross over design separated by at least 7 days. In one trial, participants exercised to cause dehydration of ~2.5% body weight loss. For the other trials, participants were required to be in a rested and euhydrated state. A set volume of alcohol was then consumed in each trial and participants were monitored over a 4 h period. Blood (BAC) and breath (BrAC) alcohol samples were ...
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    This study investigated the influence of exercise-induced dehydration on alcohol pharmacokinetics, subjective ratings of impairment, and risk-taking behaviours. Twelve male volunteers participated in 3 experimental trials completed in a randomised cross over design separated by at least 7 days. In one trial, participants exercised to cause dehydration of ~2.5% body weight loss. For the other trials, participants were required to be in a rested and euhydrated state. A set volume of alcohol was then consumed in each trial and participants were monitored over a 4 h period. Blood (BAC) and breath (BrAC) alcohol samples were collected throughout and analysed to calculate pharmacokinetic variables associatedwith the blood alcohol curve. Total urine production, estimates of BrAC, and subjective ratings of intoxication and impairment were also recorded throughout each trial. No difference was found in the pharmacokinetics of alcohol between any of the trial conditions. BrACs were higher than BACs for 2 h following alcohol consumption, but lower at measures taken 3 and 4 h post ingestion. Participants' ratings of confusion and intoxication were significantly lower, and they were more willing to drive in the dehydration trial comparedwith one of the euhydration trials. These findings suggest that dehydration or other physiological changes associated with exercise may have an ability to influence the subjective effects of alcohol and increase the likelihood of risk-taking behaviours such as drink-driving.However, further research is required to examine the effects of alcohol under conditions of exercise-induced fluid loss in order to clarify these findings.
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    Journal Title
    Pharmacology, Biochemistry and Behavior
    Volume
    101
    Issue
    4
    DOI
    https://doi.org/10.1016/j.pbb.2012.02.016
    Subject
    Clinical and Sports Nutrition
    Pharmacology and Pharmaceutical Sciences
    Publication URI
    http://hdl.handle.net/10072/47726
    Collection
    • Journal articles

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