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dc.contributor.authorGoodwin, Alisonen_US
dc.contributor.authorLeveritt, Michaelen_US
dc.contributor.authorDavey, Andrewen_US
dc.contributor.authorDesbrow, Benen_US
dc.date.accessioned2017-05-03T14:11:45Z
dc.date.available2017-05-03T14:11:45Z
dc.date.issued2012en_US
dc.date.modified2013-06-06T23:27:21Z
dc.identifier.issn00913057en_US
dc.identifier.doi10.1016/j.pbb.2012.02.016en_US
dc.identifier.urihttp://hdl.handle.net/10072/47726
dc.description.abstractThis study investigated the influence of exercise-induced dehydration on alcohol pharmacokinetics, subjective ratings of impairment, and risk-taking behaviours. Twelve male volunteers participated in 3 experimental trials completed in a randomised cross over design separated by at least 7 days. In one trial, participants exercised to cause dehydration of ~2.5% body weight loss. For the other trials, participants were required to be in a rested and euhydrated state. A set volume of alcohol was then consumed in each trial and participants were monitored over a 4 h period. Blood (BAC) and breath (BrAC) alcohol samples were collected throughout and analysed to calculate pharmacokinetic variables associatedwith the blood alcohol curve. Total urine production, estimates of BrAC, and subjective ratings of intoxication and impairment were also recorded throughout each trial. No difference was found in the pharmacokinetics of alcohol between any of the trial conditions. BrACs were higher than BACs for 2 h following alcohol consumption, but lower at measures taken 3 and 4 h post ingestion. Participants' ratings of confusion and intoxication were significantly lower, and they were more willing to drive in the dehydration trial comparedwith one of the euhydration trials. These findings suggest that dehydration or other physiological changes associated with exercise may have an ability to influence the subjective effects of alcohol and increase the likelihood of risk-taking behaviours such as drink-driving.However, further research is required to examine the effects of alcohol under conditions of exercise-induced fluid loss in order to clarify these findings.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom609en_US
dc.relation.ispartofpageto616en_US
dc.relation.ispartofissue4en_US
dc.relation.ispartofjournalPharmacology, Biochemistry and Behavioren_US
dc.relation.ispartofvolume101en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchClinical and Sports Nutritionen_US
dc.subject.fieldofresearchcode111101en_US
dc.titleAlcohol pharmacokinetics and risk-taking behaviour following exercise-induced dehydrationen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Public Healthen_US
gro.date.issued2012
gro.hasfulltextNo Full Text


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