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dc.contributor.authorGreenwood, Christina
dc.contributor.authorMetodieva, Gergana
dc.contributor.authorAl-Janabi, Khalid
dc.contributor.authorLausen, Berthold
dc.contributor.authorAlldridge, Louise
dc.contributor.authorLeng, Lin
dc.contributor.authorBucala, Richard
dc.contributor.authorFernandez, Nelson
dc.contributor.authorV. Metodiev, Metodi
dc.date.accessioned2017-05-03T15:27:59Z
dc.date.available2017-05-03T15:27:59Z
dc.date.issued2012
dc.date.modified2013-06-05T02:37:02Z
dc.identifier.issn1874-3919
dc.identifier.doi10.1016/j.jprot.2011.11.033
dc.identifier.urihttp://hdl.handle.net/10072/47753
dc.description.abstractTriple-negative breast cancer is difficult to treat because of the lack of rationale-based therapies. There are no established markers and targets that can be used for stratification of patients and targeted therapy. Here we report the identification of novel molecular features, which appear to augment metastasis of triple negative breast tumors. We found that triple-negative breast tumors can be segregated into 2 phenotypes based on their genome-wide protein abundance profiles. The first is characterized by high expression of Stat1, Mx1, and CD74. Seven out of 9 tumors from this group had invaded at least 2 lymph nodes while only 1 out of 10 tumors in group 2 was lymph node positive. In vitro experiments showed that the interferon-induced increase in Stat1 abundance correlates with increased migration and invasion in cultured cells. When CD74 was overexpressed, it increased cell adhesion on matrigel. This effect was accompanied with a marked increase in the membrane expression of beta-catenin, MUC18, plexins, integrins, and other proteins involved in cell adhesion and cancer metastasis. Taken together, our results show that Stat1/CD74 positive triple-negative tumors are more aggressive and suggest an approach for development of better diagnostics and more targeted therapies for triple negative breast cancer.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom3031
dc.relation.ispartofpageto3040
dc.relation.ispartofissue10
dc.relation.ispartofjournalJournal of Proteomics
dc.relation.ispartofvolume75
dc.rights.retentionY
dc.subject.fieldofresearchSignal Transduction
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchPlant Biology
dc.subject.fieldofresearchcode060111
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode0607
dc.titleStat1 and CD74 overexpression is co-dependent and linked to increased invasion and lymph node metastasis in triple-negative breast cancer
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2012
gro.hasfulltextNo Full Text
gro.griffith.authorAlldridge, Louise C.


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