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dc.contributor.authorLose, Felicity
dc.contributor.authorSrinivasan, Srilakshmi
dc.contributor.authorO'Mara, Tracy
dc.contributor.authorMarquart, Louise
dc.contributor.authorChambers, Suzanne
dc.contributor.authorGardiner, Robert A
dc.contributor.authorAitken, Joanne F
dc.contributor.authorSpurdle, Amanda B
dc.contributor.authorBatra, Jyotsna
dc.contributor.authorClements, Judith A
dc.date.accessioned2017-05-03T13:08:11Z
dc.date.available2017-05-03T13:08:11Z
dc.date.issued2012
dc.date.modified2013-06-14T05:17:41Z
dc.identifier.issn1932-6203
dc.identifier.doi10.1371/journal.pone.0044520
dc.identifier.urihttp://hdl.handle.net/10072/47773
dc.description.abstractThe Kallikrein-related peptidase, KLK4, has been shown to be significantly overexpressed in prostate tumours in numerous studies and is suggested to be a potential biomarker for prostate cancer. KLK4 may also play a role in prostate cancer progression through its involvement in epithelial-mesenchymal transition, a more aggressive phenotype, and metastases to bone. It is well known that genetic variation has the potential to affect gene expression and/or various protein characteristics and hence we sought to investigate the possible role of single nucleotide polymorphisms (SNPs) in the KLK4 gene in prostate cancer. Assessment of 61 SNPs in the KLK4 locus (610 kb) in approximately 1300 prostate cancer cases and 1300 male controls for associations with prostate cancer risk and/or prostate tumour aggressiveness (Gleason score ,7 versus $7) revealed 7 SNPs to be associated with a decreased risk of prostate cancer at the Ptrend,0.05 significance level. Three of these SNPs, rs268923, rs56112930 and the HapMap tagSNP rs7248321, are located several kb upstream of KLK4; rs1654551 encodes a non-synonymous serine to alanine substitution at position 22 of the long isoform of the KLK4 protein, and the remaining 3 risk-associated SNPs, rs1701927, rs1090649 and rs806019, are located downstream of KLK4 and are in high linkage disequilibrium with each other (r2$0.98). Our findings provide suggestive evidence of a role for genetic variation in the KLK4 locus in prostate cancer predisposition.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent212822 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherPublic Library of Science
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrome44520-1
dc.relation.ispartofpagetoe44520-14
dc.relation.ispartofissue9
dc.relation.ispartofjournalPloS One
dc.relation.ispartofvolume7
dc.rights.retentionY
dc.subject.fieldofresearchCancer genetics
dc.subject.fieldofresearchcode321103
dc.titleGenetic Association of the KLK4 Locus with Risk of Prostate Cancer
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://www.plos.org/journals/license.html
gro.rights.copyright© 2012 Lose et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License CCAL. (http://www.plos.org/journals/license.html)
gro.date.issued2012
gro.hasfulltextFull Text
gro.griffith.authorChambers, Suzanne K.


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