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dc.contributor.authorM, Yudien_US
dc.contributor.authorL, Omeraen_US
dc.contributor.authorN, McCubberyen_US
dc.contributor.authorS, Dicken_US
dc.contributor.authorJayasinghe, Satyajiten_US
dc.contributor.authorHamilton-Craig, Ianen_US
dc.date.accessioned2017-04-24T11:36:41Z
dc.date.available2017-04-24T11:36:41Z
dc.date.issued2012en_US
dc.date.modified2014-10-09T00:55:55Z
dc.identifier.issn0037-5675en_US
dc.identifier.urihttp://hdl.handle.net/10072/47776
dc.description.abstractIntroduction Familial hypercholesterolaemia (FH) is caused by an autosomal dominant mutation of the low density lipoprotein (LDL) receptor gene, resulting in high levels of LDL cholesterol and premature coronary artery disease (P-CAD). Studies have shown low detection rates of FH in patients admitted with P-CAD and suboptimal therapy at discharge. Methods Males aged = 55 years and females aged = 60 years who were admitted with P-CAD to the Gold Coast Hospital during a 12-month period were included in the study. The demographics, cardiovascular risk factors, examination findings, admission and discharge cardiac medications and provisional diagnoses were recorded. Diagnosis of FH was made according to internationally accepted criteria. Resu lts 210 patients were included in the study; 60% were male and 40% female (mean age 48 and 50 years, respectively). Only 96 (46%) patients' fasting lipid levels were documented (LDL-C 2.75 ᠱ.0 mmol/L), and FH was considered in three (1%) cases. According to the Dutch Lipid Network criteria, three (1%) patients had probable FH, 50 (24%) had possible FH and 60 (29%) had unlikely FH. Of the 53 patients with probable or possible FH, 12 (23%) were discharged without statin therapy and 13 (25%) on the maximum recommended statin dose. Conclusion Our study has found inadequate documentation and screening for FH and suboptimal therapy in patients admitted with P-CAD. We propose a simple screening tool that can be applied to all patients admitted with suspected P-CAD in order to improve the detection rate of FH and its management.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherSingapore Medical Associationen_US
dc.publisher.placeSingaporeen_US
dc.publisher.urihttp://www.sma.org.sg/Publications/articles.aspx?ID=BF2D7B8D-5178-4DC7-AFB7-2D83161FB991en_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom174en_US
dc.relation.ispartofpageto178en_US
dc.relation.ispartofissue3en_US
dc.relation.ispartofjournalSingapore Medical Journalen_US
dc.relation.ispartofvolume53en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classifieden_US
dc.subject.fieldofresearchcode119999en_US
dc.titleSuboptimal consideration and management of potential familial hypercholesterolaemia in patients with suspected premature coronary artery diseaseen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2012
gro.hasfulltextNo Full Text


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